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Structure of the agonist-bound neurotensin receptor
Neurotensin (NTS) is a 13-amino-acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1, a G-protein-coupled receptor (GPCR). In… Expand
Tembusu Virus in Ducks, China
- Zhenzhen Cao, C. Zhang, +17 authors D. Zhang
- Medicine, Biology
- Emerging infectious diseases
- 1 October 2011
In China in 2010, a disease outbreak in egg-laying ducks was associated with a flavivirus. The virus was isolated and partially sequenced. The isolate exhibited 87%–91% identity with strains of… Expand
Advances in paper-based point-of-care diagnostics.
Paper-based diagnostics are affordable, user-friendly, rapid, robust, and scalable for manufacturing, thus holding great potential to deliver point-of-care (POC) diagnostics to resource-limited settings. Expand
Non-Fourier analysis of skin biothermomechanics
Abstract Biothermomechanics of skin is highly interdisciplinary, involving bioheat transfer, burn damage, biomechanics and physiology. Comprehension of the phenomena of heat transfer and related… Expand
Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information
We describe an update of the Therapeutic Target Database (TTD) previously featured in NAR. Expand
Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.
BACKGROUND ExteNET showed that 1 year of neratinib, an irreversible pan-HER tyrosine kinase inhibitor, significantly improves 2-year invasive disease-free survival after trastuzumab-based adjuvant… Expand
Proteomics-based identification of a group of apoptosis-related proteins and biomarkers in gastric cancer.
- Zhi-gang Bai, Y. Ye, +8 authors Shan Wang
- Biology, Medicine
- International journal of oncology
- 1 February 2011
Gastric cancer (GC) is the one of the most common types of cancer in Asia. To better understand the molecular mechanisms underlying GC, and to seek new markers of tumor progression, we used a… Expand
Advances in developing HIV-1 viral load assays for resource-limited settings.
Commercial HIV-1 RNA viral load assays have been routinely used in developed countries to monitor antiretroviral treatment (ART). However, these assays require expensive equipment and reagents,… Expand
Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3.
- M. Johnson, An-rong Li, +19 authors J. Medina
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 June 2007
A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized and their affinity for the receptor evaluated. Compounds were evaluated in a (125)I-IP10 displacement assay… Expand
Biomass Converting Enzymes as Industrial Biocatalysts for Fuels and Chemicals: Recent Developments
The economic utilization of abundant lignocellulosic biomass as a feedstock for the production of fuel and chemicals would represent a profound shift in industrial carbon utilization, allowing… Expand