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N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis
Wnt signalling has pivotal roles in tumour progression and metastasis; however, the exact molecular mechanism of Wnt signalling in the metastatic process is as yet poorly defined. Here we demonstrateExpand
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Cancer associated fibroblasts (CAFs) in tumor microenvironment.
Cancer associated fibroblasts (CAFs) is one of the most crucial components of the tumor microenvironment which promotes the growth and invasion of cancer cells by various mechanisms. CAFs demonstrateExpand
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Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch inExpand
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miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4.
Despite significant improvement in survival rates of patients with breast cancer, prognosis of metastatic disease is still dismal. Cancer stem-like cells (CSC) are considered to play a role inExpand
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Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells
Notch signaling is often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorlyExpand
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Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
BMP7 released by bone marrow stromal cells induces reversible senescence of prostate cancer stem-like cells, and BMPR2 expression inversely correlates with bone metastasis and recurrence in prostateExpand
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Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain
Brain metastasis of breast cancer profoundly affects the cognitive and sensory functions as well as morbidity of patients, and the 1 year survival rate among these patients remains less than 20%.Expand
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Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer
Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic pathway is known to cause tumor cell death by apoptosis. However, the exact role of lipogenesis in tumor initiation isExpand
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RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer.
RhoC is a member of the Ras-homologous family of genes which have been implicated in tumorigenesis and tumor progression. However, the exact role of RhoC is controversial and is yet to be clarified.Expand
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Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
Resveratrol is a natural polyphenolic compound and has been shown to exhibit cardio-protective as well as anti-neoplastic effects on various types of cancers. However, the exact mechanism of itsExpand
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