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Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair
ABSTRACT The pathway determining malignant cellular transformation, which depends upon mutation of the BRCA1 tumor suppressor gene, is poorly defined. A growing body of evidence suggests thatExpand
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Hdac3 is essential for the maintenance of chromatin structure and genome stability.
Hdac3 is essential for efficient DNA replication and DNA damage control. Deletion of Hdac3 impaired DNA repair and greatly reduced chromatin compaction and heterochromatin content. These defectsExpand
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The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.
In this study, we examine the potential role of receptor-associated protein 80 (RAP80), a nuclear protein containing two ubiquitin-interacting motifs (UIM), in DNA damage response and double-strandExpand
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Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
Carriers of BRCA2 germline mutations are at high risk to develop early-onset breast cancer. The underlying mechanisms of how BRCA2 inactivation predisposes to malignant transformation have not beenExpand
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Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.
Mutations in the BRCA1 or BRCA2 genes predispose to a wide spectrum of familial cancers. The functions of the proteins encoded by BRCA1 and BRCA2 remain to be elucidated, but their interaction andExpand
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Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining.
The tumor suppressor gene BRCA1 maintains genomic integrity by protecting cells from the deleterious effects of DNA double-strand breaks (DSBs). Through its interactions with the checkpoint kinase 2Expand
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BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1 Phase of the Cell Cycle*
Background: Quality control of DNA double-strand break repair is poorly understood. Results: BRCA1 enhances the fidelity of NHEJ repair and prevents mutagenic deletional end-joining throughExpand
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Basic Mechanisms of Therapeutic Resistance to Radiation and Chemotherapy in Lung Cancer
AbstractIn recent years, there have been multiple breakthroughs in our understanding of lung cancer biology. Despite significant advances in molecular targeted therapies, DNA-damaging cytotoxicExpand
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Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells.
The epidermal growth factor receptor (EGFR) family has been implicated in several cancers, including breast, and its members have become the target of novel cancer therapies. In this report, we showExpand
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Ionizing radiation-induced DNA damage, response, and repair.
SIGNIFICANCE Ionizing radiation (IR) is an effective and commonly employed treatment in the management of more than half of human malignancies. Because IR's ability to control tumors mainly relies onExpand
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