• Publications
  • Influence
Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregation.
We report a simple method to microencapsulate erythropoietin (EPO, a protein easily denatured and antigenized by contact with water-organic solvent interfaces) into poly(lactic-co-glycolic acid)Expand
  • 54
  • 5
Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents.
We report a method to load proteins into polymer-based sustained-release systems without exposing them to water-oil or water-air interfaces, factors known to denature proteins. By dispersing a dextanExpand
  • 51
  • 4
Analysis of energy-related CO2 emissions in China's pharmaceutical industry and its driving forces
Abstract China's pharmaceutical industry has experienced a rapid growth and is now facing a great challenge of reducing its CO2 emission. However, a detailed study concerning its energy consumptionExpand
  • 14
  • 2
Polyspermine imidazole-4,5-imine, a chemically dynamic and biologically responsive carrier system for intracellular delivery of siRNA.
SUMMARY We report a structurally simple yet highly functional cationic polymer, polyspermine imidazole-4,5-imine, which accomplishes four of the total five essential tasks to achieve therapeuticallyExpand
  • 43
  • 1
Preparation of polysaccharide glassy microparticles with stabilization of proteins.
This study investigates a method of preparing hazard-resistant protein-loaded polysaccharide glassy microparticles using freezing-induced phase separation method without exposure to water/oil,Expand
  • 43
  • 1
Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion.
A novel method has been developed to protect protein drugs in poly (lactic-co-glycolic acid) (PLGA) microspheres using S/O/O/W multi-emulsion method. This method develops a novel protein drugExpand
  • 53
  • 1
Polymersomes of asymmetric bilayer membrane formed by phase-guided assembly.
Encapsulating delicate biomolecules into submicron-sized polymer particulate systems with preserved native conformation and sufficient loading efficiency is of great challenge. To address this issue,Expand
  • 40
  • 1
Hydrogel Microneedle Arrays for Transdermal Drug Delivery
Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25–2000 μm inExpand
  • 38
  • 1
Mono-PEGylated radix ophiopogonis polysaccharide for the treatment of myocardial ischemia.
  • G. Sun, X. Lin, +4 authors Y. Feng
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 16 July 2013
This work aimed to improve the clinical application of Radix Ophiopogonis polysaccharide (ROP), a natural anti-myocardial ischemic fructan with Mw of 4.80 kDa, by mono-PEGylation. ThreeExpand
  • 17
  • 1
Novel approach to synthesizing hydrophobically associating copolymer using template copolymerization: the synthesis and behaviors of acrylamide and 4-(omega-propenoyloxyethoxy) benzoic acid copolymer.
Hydrophobically associating copolymers of acrylamide (AM) with a small amount of 4-(omega-propenoyloxyethoxy) benzoic acid (PEBA, <2.5%) were synthesized by template copolymerization in the presenceExpand
  • 24
  • 1