Complete nucleotide sequence of the AIDS virus, HTLV-III
The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The…
Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders.
A novel human B-lymphotropic virus (HBLV) was isolated from the peripheral blood leukocytes of six individuals and selectively infected freshly isolated human B cells and converted them into large, refractile mono- or binucleated cells with nuclear and cytoplasmic inclusion bodies.
Restricted expression of human T-cell leukemia--lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes.
A new reporter cell line to monitor HIV infection and drug susceptibility in vitro.
- A. Gervaix, D. West, L. Leoni, D. Richman, F. Wong-Staal, J. Corbeil
- Biology, MedicineProceedings of the National Academy of Sciences…
- 29 April 1997
The CEM-GFP reporter cell line provides a simple, rapid, and direct method for monitoring HIV infectivity titers and antiretroviral drug susceptibility of syncytium-inducing strains.
Complete nucleotide sequences of functional clones of the AIDS virus.
The complete nucleotide sequence of the proviral form of HXB2 has now been determined and its structure is quite similar to that previously determined for HTLV-III/LAV clones whose biological capacities had not previously been demonstrated.
The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.
Results indicate that the pX protein is essential for the replication cycle of the virus and that it may be directly involved in the immortalization of human lymphocytes by HTLV-I.
Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).
Human T-lymphotropic virus type III (HTLV-III) encodes a trans-acting factor that activates the expression of genes linked to the HTLV-III long terminal repeat. By functional mapping of complementary…
The sor gene of HIV-1 is required for efficient virus transmission in vitro.
The data suggest that sor influences virus replication at a novel, post-translational stage and that its action is independent of the regulatory genes tat and trs.
Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission
It is demonstrated that, in contrast to earlier reports, CD81 and the tight-junction components claudin-1 and occludin are all essential for both cell-free and cell-to-cell viral transmission of Hepatitis C virus, however, scavenger receptor BI (SR-BI) has a more prominent role in cell- to-cell transmission of the virus.
Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors
The experiments delineate mechanisms involved in species-restricted replication of this lentivirus and show that human cells support both productive- and infective-phase mechanisms of the FIV life cycle needed for efficient lentiviral vector transduction.