• Publications
  • Influence
The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators.
TLDR
Specific consensus-based recommendations were made regarding the definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators for mucous membrane pemphigoid.
A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.
TLDR
The presence of a T allele in exon 7 (position 18067) of the XRCC3 gene was significantly associated with melanoma development, and may provide further insights into the pathogenesis and the mechanism of UV-radiation induced carcinogenesis as well as having a role in prevention.
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome.
TLDR
Kindler syndrome is, to the authors' knowledge, the first skin fragility disorder caused by a defect in actin-ECM linkage, rather than keratin- ECM linkage.
Childhood vulvar lichen sclerosus: an increasingly common problem.
TLDR
Although the cause of LS remains uncertain, it is not a rare disease in prepubertal girls and current optimal management includes prompt diagnosis and institution of treatment with a potent topical steroid.
Does treatment of vulvar lichen sclerosus influence its prognosis?
TLDR
Topical ultrapotent steroid is an effective treatment for vulvar lichen sclerosus, giving relief of symptoms in most and completely reversing the skin changes in approximately one fifth of patients.
The high rate of familial lichen sclerosus suggests a genetic contribution: an observational cohort study
TLDR
Familial lichen sclerosus has been described in only 37 families and the association is under‐reported, so the association should be reported on a case-by-case basis.
Mucosal involvement in systemic and chronic cutaneous lupus erythematosus
TLDR
The prevalence of mucosal involvement in lupus is underestimated as the lesions may be asymptomatic, and these were associated with conjunctival scarring in two patients.
Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin
TLDR
Epidermodysplasia verruciformis HPV types are those most plausibly linked to the development of squamous cell carcinomas of the skin.
Evidence‐based (S3) Guideline on (anogenital) Lichen sclerosus
TLDR
The gold standard for treatment remains potent to very potent topical steroids; however, mild and moderate disease in boys and men may be cured by circumcision.
Interventions for bullous pemphigoid.
TLDR
Very potent topical steroids are effective and safe treatments for bullous pemphigoid; their use in extensive disease may be limited by side effects and practical factors.
...
1
2
3
4
5
...