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Impact of Body Mass and Body Composition on Circulating Levels of Natriuretic Peptides: Results From the Dallas Heart Study
TLDR
These findings do not support the hypothesis that the lower BNP levels seen in obesity are driven by enhanced BNP clearance mediated via NPR-C, and both BNP and NT-proBNP are more closely associated with lean mass than with fat mass. Expand
Prevalence and Determinants of Troponin T Elevation in the General Population
TLDR
In the general population, cTnT elevation is rare in subjects without CHF, LVH, CKD, DM, or DM, suggesting that the upper limit of normal for the immunoassay should be <0.01 &mgr;g/L. Expand
ROC curves in clinical chemistry: uses, misuses, and possible solutions.
TLDR
How the accuracy of clinical laboratory diagnostic tests is assessed, compared, and reported in the literature is observed; common problems with the use of ROC curves are identified; and some possible solutions are offered to offer. Expand
Race and gender differences in C-reactive protein levels.
TLDR
Significant race and gender differences exist in the population distribution of C-reactive protein (CRP) levels, and whether thresholds for cardiovascular risk assessment should be adjusted for differentrace and gender groups is investigated. Expand
Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice.
TLDR
The low II indicates that population-based reference intervals are less useful for interpreting cTnI values than following serial changes in values in individual patients. Expand
Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder.
TLDR
Nomograms that incorporate urinary NMP22, cytology, age and gender to predict with high accuracy the probability of disease recurrence and progression in patients with Ta, T1, and/or CIS bladder TCC are developed and validated. Expand
Interlaboratory standardization of measurements of glycohemoglobins.
TLDR
Calibration decreased between-method variability and improved interassay precision and allows direct comparison of results obtained by different methods and improves precision in GHb measurements. Expand
Clinical Laboratory Tests: Which, Why, and What Do The Results Mean?
TLDR
The days of a “shotgun approach” to ordering laboratory tests has, of necessity, been replaced by a "rifle" approach based on an understanding of the test’s diagnostic performance and the major “legitimate” reasons for ordering a laboratory test. Expand
Evaluation of neurologic function in Gulf War veterans. A blinded case-control study.
TLDR
The 3 factor-derived syndromes identified among Gulf War veterans appear to represent variants of a generalized injury to the nervous system. Expand
Assessment of HER-2/neu status in breast cancer. Automated Cellular Imaging System (ACIS)-assisted quantitation of immunohistochemical assay achieves high accuracy in comparison with fluorescence in
TLDR
A new image analyzer-assisted immunohistochemical quantitation method, using fluorescence in situ hybridization assay (FISH) as the standard, which represents a substantial improvement over the manual method for objective evaluation of the HER-2/neu status. Expand
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