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  • Influence
Enhanced Reactivity and Vulnerability to Cocaine Following Methylphenidate Treatment in Adolescent Rats
Treatment of attention deficit hyperactivity disorder with the psychostimulant drug methylphenidate (MP) has increased dramatically among schoolchildren. We tested whether repeated exposure toExpand
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Differential effects of classical and atypical antipsychotic drugs on A9 and A10 dopamine neurons.
Prolonged treatment with classical antipsychotic drugs decreased the number of spontaneously active dopamine neurons in both the substantia nigra (A9) and the ventral tegmental area (A10) of the ratExpand
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Regulation of dopaminergic transmission and cocaine reward by the Clock gene.
Although there are clear interactions between circadian rhythms and drug addiction, mechanisms for such interactions remain unknown. Here we establish a role for the Clock gene in regulating theExpand
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Synaptic regulation of mesocorticolimbic dopamine neurons.
  • F. White
  • Biology, Medicine
  • Annual review of neuroscience
  • 1996
The mesocorticolimbic dopamine system is thought to be involved in psychosis and drug addiction. Many intrinsic membrane properties and synaptic regulators have been identified and characterized inExpand
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Dopamine D3 Receptor Mutant Mice Exhibit Increased Behavioral Sensitivity to Concurrent Stimulation of D1 and D2 Receptors
The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant miceExpand
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DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3′,5′-monophosphate–regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in allExpand
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Neuroadaptations involved in amphetamine and cocaine addiction.
Ž . Psychomotor stimulants or psychostimulants can be defined as drugs that elicit behavioral activation at doses typically employed for therapeutic or recreatioŽ . nal purposes O’Brien et al., 1992Expand
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Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system.
The development of behavioral sensitization during repeated administration of psychomotor stimulants is a well characterized phenomenon which involves alterations in dopaminergic neurotransmissionExpand
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Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: repeated administration.
Behavioral evidence indicates that the potent rewarding effects of cocaine are mediated, in part, by the mesoaccumbens dopamine (DA) system projecting from A10 DA cells in the ventral tegmental areaExpand
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Whole-Cell Plasticity in Cocaine Withdrawal: Reduced Sodium Currents in Nucleus Accumbens Neurons
The nucleus accumbens is a forebrain region that mediates cocaine self-administration and withdrawal effects in animal models of cocaine dependence. Considerable evidence suggests an important roleExpand
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