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Serum Adiponectin Level May be an Independent Predictor of Clear Cell Renal Cell Carcinoma
Lower plasma adiponectin concentration was related to an increased incidence ofccRCC and may act as an independent predictor for ccRCC. Expand
AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.
This study reports that NANOG is degraded by SPOP, a frequently mutated tumor suppressor of PCa, and provides a regulation mechanism ofPCa stemness controlled by phosphorylation-mediated NANog stability, which helps to identify novel drug targets and improve therapeutic strategy for PCa. Expand
ADIPOQ polymorphism rs182052 is associated with clear cell renal cell carcinoma
The results suggest that ADIPOQ rs182052 is significantly associated with ccRCC risk, and this positive association was more evident in overweight subjects. Expand
Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
An assay that thermophoretically profiles surface proteins from serum extracellular vesicles labelled with a panel of fluorescent aptamers detects and classifies patients according to cancer type and cancer stage, and if validated in larger cohorts may facilitate cancer screening, classification and monitoring. Expand
A Prospective Trial of 68Ga-PSMA and 18F-FDG PET/CT in Nonmetastatic Prostate Cancer Patients with an Early PSA Progression During Castration
A high prevalence of N+/M+ disease and a significant proportion of PSMA-FDG+ disease in patients with an early PSA progression during castration is observed and suitability for oligometastases-directed therapy (OMDT) is evaluated. Expand
Risk Factors for Upstaging, Recurrence, and Mortality in Clinical T1-2 Renal Cell Carcinoma Patients Upstaged to pT3a Disease: an International Analysis Utilizing the 8th Edition of the…
Risk of pT3a-upstaging and recurrence in pT1-T2 RCC correlates with clinical stage at presentation, and Renal vein and perinephric fat invasion were associated with increased risk of recurrence. Expand
Is it Safe to Omit Baseline Bone Scan for Newly Diagnosed Prostate Cancer Patients?
It is demonstrated that a baseline bone scan can be safely omitted for cT1-T3 PCa patients who have a PSA ≤39 ng/ml and an ALP ≤88 IU/l. Expand
Identification and validation of an eight‐gene expression signature for predicting high Fuhrman grade renal cell carcinoma
Using three‐stage design, an eight‐gene expression signature for predicting high Fuhrman grade of clear cell renal cell carcinoma is validated and may help to reveal the characteristics of ccRCC biopsy specimens. Expand
Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients
Investigation of the potential role of the COL6A1 gene, which encodes the α1 polypeptide of collagen VI, in the biological functions involved in the progression and outcome of clear cell renal cell carcinoma found it correlates with poor prognosis in ccRCC patients. Expand
Oncologic and Functional Outcomes of Radical and Partial Nephrectomy in pT3a Pathologically Upstaged Renal Cell Carcinoma: A Multi-institutional Analysis.
In pathologically upstaged pT3a RCC, PN did not adversely affect risk of recurrence and provided functional benefit, and Surgical decision-making in patients at risk for T3a upstaging should be individualized and driven by tumor as well as functional risks. Expand