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Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects.
Osteomyelitis Associated with Vascular Insufficiency The special problems connected with the presentation, clinical course, prognosis and treatment of osteomyelitis associated with vascular insuffi...
Fibronectin, fibrinogen, and laminin act as mediators of adherence of clinical staphylococcal isolates to foreign material.
Adherence of clinical staphylococcal isolates to foreign surfaces is significantly increased by fibronectin, fibrinogen, and laminin, an observation suggesting the possible contribution of these proteins to the pathogenesis of iv device infection. Expand
Osteomyelitis: the past decade.
The high success rate observed with antibiotic therapy in most bacterial diseases contrasts with the substantial failure rate in the treatment of bone infections, which can be partly explained by the fact that bone infections are known to be difficult to treat with antibiotics. Expand
Pathogenesis of foreign body infection: description and characteristics of an animal model.
An animal model involving the subcutaneous implantation of tissue cages into guinea pigs and subsequent infection with Staphylococcus aureus was used for study factors pertinent to foreign bodyExpand
Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils
The results indicate that the secretion from three different granule populations within the same cell type are differently modulated by [Ca2+]i, and the additional signal provided by receptor activation markedly lower(s) the Ca2+ requirement of the exocytotic process. Expand
Foreign body infections due to Staphylococcus epidermidis
The pathogenesis, prevention, and treatment of implant infections due to S. epidermidis are reviewed and some new compounds with already promising in vitro results are highlighted. Expand
Host factors selectively increase staphylococcal adherence on inserted catheters: a role for fibronectin and fibrinogen or fibrin.
Results obtained with coagulase-negative isolates suggested that in vivo-deposited fibronectin is also a critical determinant in this process. Expand
Treatment of experimental foreign body infection caused by methicillin-resistant Staphylococcus aureus
Regimens including rifampin alone or in combination with vancomycin or fleroxacin or flerschine were an effective treatment of foreign body infection due to methicillin-resistant S. aureus in reducing bacteria counts, but rifampsin monotherapy was compromised by significant emergence of resistance. Expand
Levels of free granulocyte elastase in bronchial secretions from patients with cystic fibrosis: effect of antimicrobial treatment against Pseudomonas aeruginosa.
In vitro, elastolytic activity of bronchial secretions from patients with cystic fibrosis was significantly inhibited by eglin C and an oxidation-resistant variant of alpha 1-PI, both compounds currently produced by recombinant DNA technology. Expand
Thrombospondin binds to Staphylococcus aureus and promotes staphylococcal adherence to surfaces
A role for thrombospondin as an important mediator of staphylococcal adherence to activated platelets, to blood clots, or to extracellular matrices in pyogenic infections is indicated. Expand