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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
TLDR
The introduction should supply sufficient background information to allow the reader to understand and evaluate the results of the present study without referring to previous publications on the topic.
Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi, and Pneumocystis carinii expressed in yeast
TLDR
Computer analysis supports the hypothesis of the structural difference since OSC from S. cerevisiae, A. thaliana, and T. carinii differ in some structural features critical for the interaction with the surface of lipid particles.
Yeast Oxidosqualene Cyclase (Erg7p) Is a Major Component of Lipid Particles*
TLDR
Evidence is provided that lipid particles are not only a depot for neutral lipids, but also participate in coordinate sterol metabolism and trafficking and serve as a storage site for compounds that may negatively affect membrane integrity.
Regulation of HMGCoA Reductase Activity by Policosanol and Octacosadienol, a New Synthetic Analogue of Octacosanol
TLDR
Octacosadienol was as effective as policosanol in inhibiting the upregulation of HMG coA reductase, in inducing the phosphorylation of AMPK and in downregulating the HMGCoA reduCTase mRNA.
Inhibition of the ROS-mediated cytotoxicity and genotoxicity of nano-TiO2 toward human keratinocyte cells by iron doping
Nano-TiO2 powders are widely used in sunscreen lotions as UV filters in combination with other substances. The activation of TiO2 by UV rays leads to the release of reactive oxygen species (ROS,
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