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Rho transcription factor: symmetry and binding of bicyclomycin.
- F. Vincent, M. Openshaw, M. Trautwein, S. Gaskell, H. Kohn, W. Widger
- Chemistry, BiologyBiochemistry
- 8 August 2000
It is proposed that the sequence similarity between rho and F(1)-ATP synthase extends to a similar quaternary structure and an equivalent enzyme mechanism and the proposed mechanism of RNA translocation coupled with ATP hydrolysis changes the overall symmetry of rho from C6 to C6/C3.
Self-assembly of the Vascular Endothelial Cadherin Ectodomain in a Ca2+-dependent Hexameric Structure* 210
- Pierre Legrand, S. Bibert, D. Gulino
- Biology, ChemistryThe Journal of Biological Chemistry
- 2 February 2001
A recombinant fragment encompassing the four N-terminal modules of VE-cadherin (VE-EC1–4) was shown to associate, in solution, as a stable Ca2+-dependent oligomeric structure, and this oligomer is a hexamer.
C(5)-C(5a)-modified bicyclomycins: synthesis, structure, and biochemical and biological properties.
- F. Vincent, J. Srinivasan, A. Santillán, W. Widger, H. Kohn
- Chemistry, BiologyThe Journal of organic chemistry
- 6 April 2001
It is found that extending the C(5)-C(5a) double bond with unsaturated substituents provides bicyclomycin derivatives with excellent inhibitory activities in the biochemical assay, and that enhanced inhibitory activity is observed for the C (5E) geometrical isomer compared with its C( 5Z) counterpart.
5a-formylbicyclomycin: studies on the bicyclomycin-Rho interaction.
Monomer exchange experiments using modified 3-rho amine and wild type rho demonstrated that no more than two modified subunits per rho hexamer are sufficient to halt poly C-dependent rho ATPase activity.