• Publications
  • Influence
Islet inflammation and CXCL10 in recent‐onset type 1 diabetes
Type 1 diabetes results from a T cell‐mediated destruction of insulin‐producing pancreatic β cells. Little is known on local factors contributing to migration of T cells to pancreatic tissue. WeExpand
  • 134
  • 10
CD4+CD25high regulatory T cells in human autoimmune diabetes.
In mouse models, CD4+CD25+ T cells are involved in maintenance of peripheral tolerance. In humans, a subset of CD4+CD25+ T cells expressing high levels of CD25 (CD4+CD25high) with characteristicsExpand
  • 202
  • 8
Markers of beta cell function in type 1 diabetes mellitus.
Type 1 diabetes mellitus is a multifactorial autoimmune disease characterized by destruction of insulin producing pancreatic beta cells that results in insulin deficiency and fasting hyperglycemia.Expand
  • 14
  • 3
In Type 1 Diabetes Immunocompetent Cells are Defective in IL‐16 Secretion
To the Editor: Interleukin-16 (IL-16) is a chemo-attractant factor for T cell lymphocytes, including T regulatory cells, which is released by peripheral blood mononuclear cells (PBMC) upon activationExpand
  • 5
  • 2
Impaired caspase-3 expression by peripheral T cells in chronic autoimmune thyroiditis and in autoimmune polyendocrine syndrome-2.
CONTEXT Activation-induced cell death (AICD) is a major mechanism in the regulation of peripheral tolerance, and caspase-3 represents its major executioner. AICD impairment contributes to theExpand
  • 24
  • 1
Defective lymphocyte caspase-3 expression in type 1 diabetes mellitus.
OBJECTIVE Activation-induced cell death (AICD) is a major mechanism in the regulation of peripheral tolerance and its impairment can determine the development of autoimmunity. In the present study,Expand
  • 24
  • 1
  • PDF
Insulin2 Gene (Ins2) Transcription by NOD Bone Marrow‐derived Cells Does Not Influence Autoimmune Diabetes Development in NOD‐Ins2 Knockout Mice
Insulin is a critical autoantigen for the development of autoimmune diabetes in non‐obese diabetic (NOD) mice. About 80% of NOD females and 30–40% of NOD males develop diabetes. However, Insulin2Expand
  • 12
Continuous Glucose Monitoring Profiles in Healthy Non-Diabetic Participants: A Multicenter Prospective Study.
CONTEXT Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. While data on glycemic profiles of healthy, non-diabetic individuals exists for olderExpand
  • 11
Recurrence of type 1 diabetes following simultaneous pancreas-kidney transplantation
Abstract Simultaneous pancreas-kidney transplantation (SPKT) is an important option for patients with type 1 diabetes (T1D) and end-stage renal disease. While most SPKT recipients experienceExpand
  • 2