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Differential effects of early hippocampal pathology on episodic and semantic memory.
Global anterograde amnesia is described in three patients with brain injuries that occurred in one case at birth, in another by age 4, and in the third at age 9. Magnetic resonance techniques…
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A forkhead-domain gene is mutated in a severe speech and language disorder
TLDR
It is suggested that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is involved in the developmental process that culminates in speech and language.
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The hippocampus is required for short‐term topographical memory in humans
TLDR
The results suggest that the hippocampus supports allocentric topographical processing that is indispensable when appropriately tested after even very short delays, while the presence of the sample scene can allow successful topographical perception without it, possibly via a less flexible parahippocampal representation.
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Hippocampal Volume and Everyday Memory in Children of Very Low Birth Weight
TLDR
The preterm group had significantly smaller hippocampal volumes bilaterally, despite equivalent head size, and showed specific deficits in certain aspects of everyday memory, both on objective testing and as indicated by parental questionnaires.
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Neural basis of an inherited speech and language disorder.
TLDR
The genetic mutation or deletion in this region has resulted in the abnormal development of several brain areas that appear to be critical for both orofacial movements and sequential articulation, leading to marked disruption of speech and expressive language.
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Developmental amnesia associated with early hypoxic-ischaemic injury.
TLDR
It is suggested that the degree of hypoxia-ischaemia was sufficient to produce selective damage to particularly vulnerable regions of the brain, notably the hippocampi, but was not sufficient to result in the more severe neurological and cognitive deficits that can follow hypoxic- ischaemic injury.
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Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia.
TLDR
Investigations of the KE family, half the members of which are affected by a severe disorder of speech and language, are reported, suggesting that, in the affected family members, the verbal and non-verbal deficits arise from a common impairment in the ability to sequence movement or in procedural learning.
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Language fMRI abnormalities associated with FOXP2 gene mutation
TLDR
The affected members of the KE family showed significant underactivation relative to the unaffected members in Broca's area and its right homolog, as well as in other cortical language-related regions and in the putamen.
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Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits.
TLDR
Investigation of the entire coding region of FOXP2, including alternatively spliced exons, in 49 probands affected with verbal dyspraxia and the discovery of the first nonsense mutation in FoxP2 opens the door for detailed investigations of neurodevelopment in people carrying different etiological variants of the gene.
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The effects of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval.
TLDR
It is indicated that recruitment of bilateral regions during memory retrieval, and altered patterns of effective connectivity between brain regions may be important indicators of disordered memory.
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