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SUMOylation regulates Rad18-mediated template switch
Replication by template switch is thought to mediate DNA damage-bypass and fillings of gaps. Gap-filling repair requires homologous recombination as well as Rad18- and Rad5-mediated proliferatingExpand
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HDACs link the DNA damage response, processing of double-strand breaks and autophagy
Protein acetylation is mediated by histone acetyltransferases (HATs) and deacetylases (HDACs), which influence chromatin dynamics, protein turnover and the DNA damage response. ATM and ATR mediateExpand
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Replication and Recombination Factors Contributing to Recombination-Dependent Bypass of DNA Lesions by Template Switch
Damage tolerance mechanisms mediating damage-bypass and gap-filling are crucial for genome integrity. A major damage tolerance pathway involves recombination and is referred to as template switch.Expand
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Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing
The replication checkpoint controls the integrity of replicating chromosomes by stabilizing stalled forks, thus preventing the accumulation of abnormal replication and recombination intermediatesExpand
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Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway.
Damaged DNA is an obstacle during DNA replication and a cause of genome instability and cancer. To bypass this problem, eukaryotes activate DNA damage tolerance (DDT) pathways that involveExpand
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Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex
Summary Chromosomal replication is entwined with DNA damage tolerance (DDT) and chromatin structure establishment via elusive mechanisms. Here we examined how specific replication conditionsExpand
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Acetylation: a novel link between double-strand break repair and autophagy.
Histone deacetylase (HDAC) inhibitors are clinically relevant because they are used as anticancer drugs. Recent evidence sheds light on an intriguing connection among the DNA damage response (DDR),Expand
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Molecular Pathways: Old Drugs Define New Pathways: Non-Histone Acetylation at the Crossroads of the DNA Damage Response and Autophagy
Histone deacetylases (HDAC) modulate acetylation and the function of histone and non-histone proteins. HDAC inhibitors have been developed to block the aberrant action of HDACs in cancer, and severalExpand
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Abstract B37: PARP inhibitor olaparib induces genomic instability in normal mammalian cells
Poly(ADP-ribose) polymerases (PARPs) are the first proteins involved in cellular DNA damage response pathways to be targeted by specific inhibitors for clinical benefit. Tumors with defects inExpand
Molecular Pathways Molecular Pathways : Old Drugs De fi ne New Pathways : Non-Histone Acetylation at the Crossroads of the DNA Damage Response and Autophagy
Histone deacetylases (HDAC) modulate acetylation and the function of histone and non-histone proteins. HDAC inhibitors have been developed to block the aberrant action of HDACs in cancer, and severalExpand