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Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications.
EGb 761 possesses antioxidant and free radical-scavenging activities, it reverses age-related losses in brain alpha 1-adrenergic, 5-HT1A and muscarinic receptors, protects against ischaemic neuronal death, preserves the function of the hippocampal mossy fiber system, increases hippocampal high-affinity choline uptake, and opposes the detrimental effects of ischaemia. Expand
Ginkgo biloba extracts and cancer: a research area in its infancy
Recent studies conducted with various molecular, cellular and whole animal models have revealed that leaf extracts of Ginkgo biloba may have anticancer (chemopreventive) properties that are relatedExpand
Bilobalide and neuroprotection.
  • F. V. Defeudis
  • Biology, Medicine
  • Pharmacological research
  • 1 December 2002
In vitro and ex vivo studies indicate that bilobalide has multiple mechanisms of action that may be associated with neuroprotection, including its preservation of mitochondrial ATP synthesis, its inhibition of apoptotic damage induced by staurosporine or by serum-free medium, and its suppression of hypoxia-induced membrane deterioration in the brain. Expand
Effects of single intraperitoneal injections of an extract of Ginkgo biloba (EGb 761) and its terpene trilactone constituents on barbital-induced narcosis in the mouse.
It is hypothesized that interactions with the picrotoxinin/TBPT site of GABA-regulated Cl- channels of the CNS may be involved and this information appears useful in explaining the clinically observed "vigilance-enhancing" and "antidepressant-like" actions of EGb 761. Expand
Effects of Micro-injections of L-Glutamate into the Hypothalamus on Attack and Flight Behaviour in Cats
WE have carried out experiments in which cannulae (26 gauge, insulated except for 0.25 mm at their tips) were implanted stereotaxically in six adult cats in regions of the hypothalamus that produceExpand
Effects of Ginkgo biloba extract (EGb 761) on gene expression: Possible relevance to neurological disorders and age‐associated cognitive impairment
Results indicate that the therapeutic effects of EGb 761 on cognitive impairment (dementia) may involve its action of altering gene expression, and a fundamental mechanism that may underlie EGb 661‐induced neuroprotection is identified. Expand
Cancer-related overexpression of the peripheral-type benzodiazepine receptor and cytostatic anticancer effects of Ginkgo biloba extract (EGb 761).
Treatment with EGb 761 decreased PBR mRNA levels and inhibited the proliferation of breast, glioma and hepatocarcinoma cell lines, further corroborating the previous contention that its mechanism of action is through the modification of PBR expression. Expand