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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
TLDR
This study elucidates a novel pathway in cell growth and tumorigenesis through negative regulation of FOXO3a by RAS–ERK and MDM2 and downregulates Forkhead box O 3a by directly interacting with and phosphorylating FOXO 3a at Ser 294, Ser 344 and Ser 425.
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
TLDR
A mechanism by which HBV-X protein (HBX) upregulates beta-catenin through a docking motif of GSK-3beta is reported, which is supported by immunohistochemical staining in different human tumors, including cancers of the liver, breast, kidney, and stomach.
The crosstalk of mTOR/S6K1 and Hedgehog pathways.
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
TLDR
The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
TLDR
A significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association is observed, and considerable improvements in the fine-mapping resolution of common variant association signals at several T1D susceptibility loci are observed.
Meta-analysis identifies common variants associated with body mass index in East Asians
TLDR
A meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians and three additional loci nearly reached the genome-wide significance threshold may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.
Early Detection of Pompe Disease by Newborn Screening Is Feasible: Results From the Taiwan Screening Program
TLDR
This is the first large-scale study to show that newborn screening for Pompe disease is feasible and allows for earlier diagnosis of Pompe disease and, thus, for assessment of the value of an earlier start of treatment.
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