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Phenotypic and functional features of human Th17 cells
TLDR
The demonstration of selective markers for human Th17 cells may help to understand their pathogenic role, and the identification of a subset of cells sharing features of both Th1 and Th17 may raise new issues concerning developmental and/or functional relationships between Th17 and Th1.
Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1).
TLDR
It is recommended that MEN1 patients and their families should be cared for by multidisciplinary teams comprising relevant specialists with experience in the diagnosis and treatment of patients with endocrine tumors.
Guidelines for diagnosis and therapy of MEN type 1 and type 2.
TLDR
The specific RET codon mutation correlates with the MEN2 syndromic variant, the age of onset of M TC, and the aggressiveness of MTC; consequently, that mutation should guide major management decisions, such as whether and when to perform thyroidectomy.
Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor
TLDR
It is shown that all IL-17–producing cells originate from CD161+ naive CD4+ T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the combined activity of IL-1β and IL-23.
A Clinical Outcome-Based Prospective Study on Venous Thromboembolism After Cancer Surgery: The @RISTOS Project
TLDR
In patients undergoing cancer surgery, VTE is the most common cause of death at 30 days after surgery, and a remarkable proportion of events occurring late after surgery is found.
CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2
TLDR
The specific RET codon mutation correlates with the MEN2 syndromic variant, the age of onset of M TC, and the aggressiveness of MTC; consequently, that mutation should guide major management decisions, such as whether and when to perform thyroidectomy.
Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.
TLDR
It is suggested that a critical event in the initiation of bowel inflammatory lesions in CD may involve up-regulation of IL-12 production, resulting in conditions that maximally promote type 1 T-helper immune responses.
The surgical management of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop.
TLDR
The frequency of hereditary forms of PHPT may be underappreciated and needs to be assessed with increased vigilance, and surgery is likely to benefit patients due to high cure rates, low complication rates, and the likelihood of reversing skeletal manifestations.
Emergence in Italy of Klebsiella pneumoniae Sequence Type 258 Producing KPC-3 Carbapenemase
KPC-type carbapenemases are emerging resistance determinants in Klebsiella pneumoniae and other gram-negative pathogens, being an increasingly important mechanism of acquired resistance to
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