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Integrating common and rare genetic variation in diverse human populations
An expanded public resource of genome variants in global populations supports deeper interrogation of genomic variation and its role in human disease, and serves as a step towards a high-resolution map of the landscape of human genetic variation.
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
A meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry followed up with de novo genotyping and further replication in east Asian samples provides new insights into blood pressure regulation and potential targets for intervention.
A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose
We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect genome-wide significance (p<1.5×10−7) for polymorphisms that…
Newly identified genetic risk variants for celiac disease related to the immune response
This extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways and identified seven previously unknown risk regions.
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
A genome-wide association study of type-2 diabetes in individuals of South Asian ancestry provides additional insight into mechanisms underlying T2D and shows the potential for new discovery from genetic association studies in South Asians.
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
A multiancestry genome-wide-association meta-analysis and discovered 22 new stroke risk loci, indicating mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets.
Meta-analysis identifies common variants associated with body mass index in East Asians
A meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians and three additional loci nearly reached the genome-wide significance threshold may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
A significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association is observed, and considerable improvements in the fine-mapping resolution of common variant association signals at several T1D susceptibility loci are observed.
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
This multiancestry study recommends investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G 6PD deficiency is common, and investigates the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance.