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Genome and virulence determinants of high virulence community-acquired MRSA
BACKGROUND A new type of meticillin-resistant Staphylococcus aureus (MRSA), designated community-acquired MRSA, is becoming increasingly noticeable in the community, some strains of which cause fatalExpand
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Integrating common and rare genetic variation in diverse human populations
Despite great progress in identifying genetic variants that influence human disease, most inherited risk remains unexplained. A more complete understanding requires genome-wide studies that fullyExpand
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Novel Type V Staphylococcal Cassette Chromosome mec Driven by a Novel Cassette Chromosome Recombinase, ccrC
ABSTRACT Staphylococcal cassette chromosome mec (SCCmec) is a mobile genetic element composed of the mec gene complex, which encodes methicillin resistance, and the ccr gene complex, which encodesExpand
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Two‐component system VraSR positively modulates the regulation of cell‐wall biosynthesis pathway in Staphylococcus aureus
DNA microarray covering the whole genome of Staphylococcus aureus strain N315 was prepared to investigate transcription profiles. The microarray analyses revealed that vancomycin inducesExpand
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Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed upExpand
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Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands.
Strains of Staphylococcus aureus, an important human pathogen, display up to 20% variability in their genome sequence, and most sequence information is available for human clinical isolates that haveExpand
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A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose
We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect genome-wide significance (p<1.5×10−7) for polymorphisms thatExpand
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Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG
Rheumatoid arthritis (RA) is a widely prevalent (1–3%) chronic systemic disease thought to have an autoimmune component1; both humoral1–4 and cellular5,6 mechanisms have been implicated. PrimaryExpand
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Newly identified genetic risk variants for celiac disease related to the immune response
Our genome-wide association study of celiac disease previously identified risk variants in the IL2–IL21 region. To identify additional risk variants, we genotyped 1,020 of the most stronglyExpand
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Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and 14,458 controls drawnExpand
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