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Inactivating PAPSS2 mutations in a patient with premature pubarche.
Dehydroepiandrosterone (DHEA) sulfotransferase, known as SULT2A1, converts the androgen precursor DHEA to its inactive sulfate ester, DHEAS [corrected], thereby preventing the conversion of DHEA toExpand
Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor.
High circulating MIF levels were shown to correlate strongly with radiologic joint damage, suggesting that MIF expression is genetically determined and can be used as a novel prognostic tool in RA. Expand
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.
The data suggest that disturbed expression of FcgammaR on mature synovial macrophages is involved in the pathology of RA, resulting in much higher production of TNFalpha and gelatinase/collagenase after IC stimulation. Expand
High‐sensitive radioimmunoassay for human serum hepcidin
A RadioImmunoAssay (RIA) to measure hepcidin quantitatively in human serum that is easy to perform and many samples can be processed within one assay‐run, shows accurate, reproducible and high‐sensitive measurements and is anticipated to be particularly useful to study the effects of pathological and physiological stimuli on hePCidin levels in the lower range. Expand
Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis.
MIF is markedly and persistently up-regulated in children and adults with gram-negative sepsis and is associated with parameters of disease severity, with dysregulated pituitary-adrenal function in meningococcal sepsi, and with early death. Expand
Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones
Breast cancer resistance protein (BCRP) is known for its protective function against the toxic effects of exogenous compounds. In addition to this, a role in the transport of endogenous compounds hasExpand
Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation.
A new molecular mechanism by which histone deacetylase inhibitors inhibit MIF gene expression is described, and it is suggested that macrophage migration inhibitory factor inhibition by histoneDeacetyl enzyme inhibitors may contribute to the antitumorigenic effects of hist one deacetyase inhibitors. Expand
Does stress affect the joints? Daily stressors, stress vulnerability, immune and HPA axis activity, and short-term disease and symptom fluctuations in rheumatoid arthritis
Daily stressors and the stress-vulnerability factor worrying predict indicators of the short-term course of RA disease activity and fatigue and pain, while specific cytokines predict short- term fluctuations of fatigue. Expand
Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro.
It is hypothesize that transporter-mediated efflux of testosterone precursors out of MA-10 cells is inhibited by TBBPA resulting in higher availability for testosterone production, which could not be explained by coinciding changes in expression of steroidogenic genes. Expand
Selectivity of finasteride as an in vivo inhibitor of 5alpha-reductase isozyme enzymatic activity in the human prostate.
Finasteride is a selective type II inhibitor in vivo and possibly distinct roles of the 5alpha-reductase isozymes in the normal prostate, in BPH, and during finasteride treatment are assessed. Expand