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Lenormandins A—G, new azaphilones from Hypoxylon lenormandii and Hypoxylon jaklitschii sp. nov., recognised by chemotaxonomic data
TLDR
The status of the new species was established by using molecular phylogenetic data based on ITS and partial beta-tubulin sequences, and by detailed morphological studies, revealing that this group of pigments is specific for Hypoxylon lenormandii from various geographic regions and otherwise only occurs in closely related taxa. Expand
Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease inhibitor crocapeptin.
TLDR
The crocapeptins are described here as cyclic depsipeptides, isolated from cultures of the myxobacterium Chondromyces crocatus, containing the characteristic amino-hydroxy-piperidone (Ahp)-heterocycle, which proved to be serine protease inhibitors. Expand
Developing Techniques for the Utilization of Planctomycetes As Producers of Bioactive Molecules
TLDR
A pipeline that consists of tools and procedures to cultivate Planctomycetes for the production of antimicrobial compounds in a chemically defined medium and a procedure to chemically mimic their interaction with other organisms such as cyanobacteria is described. Expand
Hymenosetin, a 3-decalinoyltetramic acid antibiotic from cultures of the ash dieback pathogen, Hymenoscyphus pseudoalbidus.
TLDR
Whether hymenosetin constitutes a defence metabolite that is produced by the pathogenic fungus to combat other microbes and fungi in the natural environment is shown. Expand
The iromycins, a new family of pyridone metabolites from Streptomyces sp. I. Structure, NOS inhibitory activity, and biosynthesis.
TLDR
A detoxification pathway of a particular secondary metabolite in the host strain is a rare observation and here it is demonstrated with the iromycin family and set prospects for both medical therapy and basic research. Expand
Structure and Biosynthesis of Crocagins: Polycyclic Posttranslationally Modified Ribosomal Peptides from Chondromyces crocatus.
TLDR
It is demonstrated that crocagin A binds to the carbon storage regulator protein CsrA, thereby inhibiting the ability of CSRA to bind to its cognate RNA target. Expand
Two xanthones and two rotameric (3⟶8) biflavonoids from the Cameroonian medicinal plant Allanblackia floribunda Oliv. (Guttiferae)
Abstract Two xanthones, 2-(3-hydroxy-3,3-dimethyldihydroallyl)-dihydro-6-deoxyisojacareubin (1) and dihydro-6-deoxyjacareubin (2), and two 3 ⟶ 8 rotameric biflavonoids,Expand
Seven New Cytotoxic and Antimicrobial Xanthoquinodins from Jugulospora vestita
TLDR
The six novel compounds, 1–3, 5–7, together with xanthoquinodin B4, were also found in the screening of other strains belonging to Jugulospora rotula, revealing the potential chemotaxonomic significance of the compound class for the genus. Expand
Cohaerins G-K, azaphilone pigments from Annulohypoxylon cohaerens and absolute stereochemistry of cohaerins C-K.
TLDR
Four azaphilones were isolated from the methanolic stromatal extract of Annulohypoxylon cohaerens together with the known metabolites cohaerins C-F and 4,5,4',5'-tetrahydroxy-1,1'-binaphthyl (BNT) and showed cytotoxic effects besides a weak antimicrobial activity. Expand
Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471.
TLDR
Bioassay-guided fractionation of antibacterial extracts from cultures of a basidiomycete from Northern Thailand yielded the terpenoid deconin A (1), whose structure was elucidated by spectral methods (NMR, HRMS) as a cuparenic/mevalonic acid conjugate. Expand
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