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Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
Mammals respond to reduced food availability by becoming more wakeful and active, yet the central pathways regulating arousal and instinctual motor programs (such as food seeking) according toExpand
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Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss of orexin-containing neurons occurs in human patients with narcolepsy.Expand
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Regulatory Roles for APJ, a Seven-transmembrane Receptor Related to Angiotensin-type 1 Receptor in Blood Pressure in Vivo*
APJ is a G-protein-coupled receptor with seven transmembrane domains, and its endogenous ligand, apelin, was identified recently. They are highly expressed in the cardiovascular system, suggestingExpand
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Redox Imbalance in Cystine/Glutamate Transporter-deficient Mice*
Cystine/glutamate transporter, designated as system x–c, mediates cystine entry in exchange for intracellular glutamate in mammalian cells. This transporter consists of two protein components, xCTExpand
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Intraocular pressure in genetically distinct mice: an update and strain survey
BackgroundLittle is known about genetic factors affecting intraocular pressure (IOP) in mice and other mammals. The purpose of this study was to determine the IOPs of genetically distinct mouseExpand
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Hypertension Induced in Pregnant Mice by Placental Renin and Maternal Angiotensinogen
Maternal hypertension is a common complication of pregnancy and its pathophysiology is poorly understood. This phenomenon was studied in an animal model by mating transgenic mice expressingExpand
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An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene
A pseudogene is a gene copy that does not produce a functional, full-length protein. The human genome is estimated to contain up to 20,000 pseudogenes. Although much effort has been devoted toExpand
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Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis
Rheumatoid arthritis (RA)-associated IgG antibodies such as anti-citrullinated protein antibodies (ACPAs) have diverse glycosylation variants; however, key sugar chains modulating the arthritogenicExpand
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Intraocular pressure in genetically distinct mice: an update and strain survey: Correction
Address: 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA, 2Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, 305, Japan, 3Howard Hughes Medical Institute at TheExpand
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Angiotensinogen-deficient mice with hypotension.
The renin-angiotensin system is an enzymatic cascade that produces a potent vasoconstrictor octapeptide angiotensin II, through its physiologically inactive intermediate decapeptide angiotensin I,Expand
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