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[Compound with bronchospasmolytical activity from the chemical class of beta-phenylethyl-aminoalkyl-xanthines (author's transl)].
TLDR
The pharmacological effects characterize reproterol as a bronchospasmolytic with preferential impact on the adrenergic beta2-receptors and its nearly non-existent cardiovascular or central nervous side effects. Expand
[General pharmacologic studies on the analgesic flupirtine].
TLDR
The general pharmacological properties of ethyl-N-[2-amino-6-(4-fluor-phenylmethylamino)pyridin-3-yl]carbama te (flupirtine, D 9998), a structural new analgesic, are described and it is pointed out that fl upirtine antagonizes the morphine-induced tail phenomenon in mice in relatively low doses. Expand
Effects of the Novel β‐Adrenergic Partial Agonist Alifedrine on Cardiac Performance in Dogs with Acute Ischemic Left Ventricular Failure
TLDR
Alifedrine markedly improved left ventricular function by balanced stimulation of the myocardium and reduction of pre- and afterload in dogs induced by coronary embolization with plastic microspheres. Expand
Influence of azelastine and some selected drugs on mucociliary clearance
TLDR
It is likely that azelastine increases the mucociliary clearance by enhancing bronchial secretion, and it is possible that the observed increase in mucus secretion may contribute to the beneficial effect of azelastsine in the treatment of respiratory diseases. Expand
Young domestic pigs for the cardiovascular assessment of inotropic drugs. Comparison with dogs.
A comparison is made of cardiovascular response to cardiotonic drugs in young domestic pigs and dogs, and the use of pigs as an alternative to dogs in cardiovascular investigations is described.
[The pharmacology of a new cardiosteroid, a partially synthetic derivative of the aglycone hellebrigenin (acrihellin)].
TLDR
In dogs and cats acrihellin increases the contractile force of the myocardium; especially in failing canine heart, it increases the force of contraction (strain-gauge) and velocity of pressure rise (dp/dt max) in classical glycoside test on cat (Hatcher's dose). Expand
Effects of the novel beta-adrenergic partial agonist alifedrine on cardiac performance in dogs with acute ischemic left ventricular failure.
TLDR
Alifedrine markedly improved left ventricular function by balanced stimulation of the myocardium and reduction of pre- and afterload in dogs induced by coronary embolization with plastic microspheres. Expand
[Pharmacological effect of tinofedrine on cerebral and peripheral hemodynamics in the dog (author's transl)].
TLDR
Comparative studies with several standard drugs of the same field of indication proved a remarkable superiority of tinofedrine in the authors' experimental conditions. Expand
Protective property of azelastine against histamine challenge of rhinal mucosa in domestic pigs.
TLDR
Intranasally instilled azelastine (A-5610, CAS 58581-89-8) prevented this histamine induced rhinorrhea without reduction of basal secretion in anaesthetized domestic pigs. Expand
Influence of various adrenergic compounds on plasma potassium levels in conscious dogs and anaesthetized domestic pigs.
TLDR
It is concluded, that the plasma potassium level is reduced mainly by beta 2-adrenoceptor stimulation and should therefore be avoided whenbeta 2-agonists are used therapeutically. Expand
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