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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
TLDR
A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia. Expand
City living and urban upbringing affect neural social stress processing in humans
TLDR
It is shown that urban upbringing and city living have dissociable impacts on social evaluative stress processing in humans, and distinct neural mechanisms for an established environmental risk factor are identified. Expand
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
TLDR
The largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10-4, achieves genome- wide significance including 18 novel loci, which provide potential new biological mechanisms for bipolar disorder. Expand
Analysis of shared heritability in common disorders of the brain
TLDR
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Expand
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
TLDR
A two-stage meta-analysis of GWAS of bipolar disorder patients and controls revealed genome-wide significant associations at two novel loci, adding to a growing list of common autosomal variants involved in BD and illustrating the power of comparing well-characterized cases to an excess of controls in GWAS. Expand
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
TLDR
For the first time, specific loci that distinguish between BD and SCZ are discovered and polygenic components underlying multiple symptom dimensions are identified that point to the utility of genetics to inform symptomology and potential treatment. Expand
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
TLDR
The largest genome-wide association study to date of DSM-IV-diagnosed AD found loci associated with AD and characterized the relationship between AD and other psychiatric and behavioral outcomes, underscoring the genetic distinction between pathological and nonpathological drinking behaviors. Expand
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
TLDR
Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression. Expand
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
TLDR
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. Expand
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
TLDR
This study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level, and whether this is confined to transdiagnostic clinical symptoms should be examined in future studies. Expand
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