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Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.
Despite having several characteristics of naïve B cells, chronic lymphocytic leukemia (CLL) cells have been shown in some cases to have somatically mutated Ig variable region genes, indicating that
CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.
TLDR
CD38 expression is an independent risk factor that can be used with IgV(H) mutations and clinical stage to select patients with B-CLL with the worst prognoses.
DNA vaccines: precision tools for activating effective immunity against cancer
TLDR
Here, the development, current performance and potential of DNA vaccines for the treatment of cancer are assessed.
Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia.
TLDR
It is shown that differing responses to IgM ligation are closely associated with V(H) gene status, and that retained responsiveness to anti-IgM contributes to the poor prognosis associated with the unmutated subset of CLL.
Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia
Despite having several characteristics of naı̈ve B cells, chronic lymphocytic leukemia (CLL) cells have been shown in some cases to have somatically mutated Ig variable region genes, indicating that
Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status.
TLDR
Stating that unmutated cases (U-CLL) have an increased ability to phosphorylate p72(Syk) in response to sIgM ligation compared to mutated cases (M-C LL), this is confirmed and further investigate this differential signaling in a large cohort by [Ca(2+)](i) mobilization.
B-cell receptor signaling in chronic lymphocytic leukemia.
TLDR
The functional significance of the BCR in CLL is discussed, strategies to target B CR signaling as an emerging therapeutic approach are described, and mapping of BCR signaling pathways identifies targets for blockade, aimed to deprive CLL cells of survival and proliferative signals.
Immunoglobulin V genes and CD38 expression in CLL.
TLDR
The finding that the mutational status of immunoglobulin (Ig) V genes correlates with identifiable disease subsets of chronic lymphocytic leukemia and is of prognostic importance has been documented and mutually corroborated by.
V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity.
TLDR
The results suggest that, although there is no evidence for germinal center formation in the brain tissue, PCNSL is derived from a B cell with features associated with location in a germineal center environment.
Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities.
TLDR
The results suggest that the clonal history of the two subsets of CLL may differ, with cases of trisomy 12 showing a minimal level of mutation and cases of 13q14 abnormality showing significant levels of mutation.
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