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Chitin-induced activation of immune signaling by the rice receptor CEBiP relies on a unique sandwich-type dimerization
TLDR
The molecular basis of chitin recognition by the rice receptor, CEBiP (chitin-elicitor binding protein), and following receptor dimerization is shown based on the results of biochemical studies, epitope mapping by saturation transfer difference NMR spectroscopy and molecular modeling/docking studies. Expand
A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping
TLDR
This review provides an update of the structural and functional data on the key actors of the replicatory machinery of SARS-CoV-2, to fill the gaps in the currently available structural data, which is mainly obtained through homology modeling. Expand
Carbohydrate recognition by RpfB from Mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses.
TLDR
The crystal structure of RpfB catalytic domain in complex with N,N',N"-triacetyl-chitotriose provides the first, to the authors' knowledge, atomic representation of ligand recognition by R pfB and demonstrates that the strongest interactions are established by the N-acetylglucosamine moiety in the central region of the enzyme binding cleft. Expand
X-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureus.
TLDR
X-ray structural results obtained in the present study provide molecular clues into the mechanism of muropeptide-induced PrkC activation and show that EC-PrkC shows no tendency to dimerize even in the presence of high concentrations of m Kuropeptides. Expand
Chemical basis of peptidoglycan discrimination by PrkC, a key kinase involved in bacterial resuscitation from dormancy.
TLDR
This work exploited the structural requirements necessary for recognition and binding and proved that muropeptides physically bind to EC-PrkC through DAP-moiety-mediated interactions with an arginine residue, Arg500, belonging to the protein C-terminal PASTA domain. Expand
Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation.
TLDR
The crystal structure of a relevant portion of RipA, containing its catalytic-domain and an extra-domain of hitherto unknown function, is reported, providing the first evidence of self-inhibition in cell-disconnecting enzymes and opens a field for the design of novel antitubercular therapeutics. Expand
Capsule-Targeting Depolymerase, Derived from Klebsiella KP36 Phage, as a Tool for the Development of Anti-Virulent Strategy
TLDR
It is found that depoKP36 was also effective against a native capsule of clinical K. pneumoniae strains, representing the K63 type, and significantly inhibited Klebsiella-induced mortality of Galleria mellonella larvae in a time-dependent manner. Expand
Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms
TLDR
C capsule depolymerases are promising antivirulence compounds that act by defeating a major resistance mechanism of K. pneumoniae against the innate immunity. Expand
Molecular Players in Tuberculosis Drug Development: Another Break in the Cell Wall.
TLDR
The current knowledge in the field of drug development against tuberculosis is reviewed with a focus on the mechanisms of action of drugs and the targeted bacterial cell processes involved, with particular emphasis on the process of cell wall synthesis. Expand
A Structural View at SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping
TLDR
This review provides an update of structural and functional data on key actors of the replicatory machinery of SARS-CoV-2, filling the gaps in the current availability of structural data using homology modelling. Expand
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