Sympathetic activation in chronic renal failure.
- M. Schlaich, F. Socratous, G. Lambert
- Biology, MedicineJournal of the American Society of Nephrology
- 1 May 2009
Analysis of potential mechanisms underlying sympathetic activation in chronic kidney disease, the range of adverse consequences associated with this activation, and potential therapeutic implications resulting from this relationship are analyzed.
Relation Between Cardiac Sympathetic Activity and Hypertensive Left Ventricular Hypertrophy
- M. Schlaich, D. Kaye, E. Lambert, M. Sommerville, F. Socratous, M. Esler
- Medicine, BiologyCirculation
- 5 August 2003
It is demonstrated that hypertensive LV hypertrophy is associated with increased sympathetic activity largely confined to the heart, suggesting that increased cardiac norepinephrine release is related to the development of LVhypertrophy.
Sympathetic Nerve Biology In Essential Hypertension
- M. Esler, M. Rumantir, G. Lambert
- Medicine, BiologyClinical and Experimental Pharmacology and…
- 1 December 2001
A key piece of evidence supporting the neurogenic basis of essential hypertension is shown, in addition to the obvious one of an increased rate of sympathetic nerve firing, of the increased spillover of noradrenaline from the kidneys and heart to plasma.
Altered Sympathetic Nervous Reactivity and Norepinephrine Transporter Expression in Patients With Postural Tachycardia Syndrome
- E. Lambert, N. Eikelis, G. Vaddadi
- Medicine, BiologyCirculation: Arrhythmia and Electrophysiology
- 1 June 2008
Patients with POTS exhibit a decrease in NET protein in their peripheral sympathetic nerves, and whole-body NE spillover to plasma during rest in the supine position and in response to head-up tilt is not altered despite excessive nerve firing rate.
Renal denervation: a potential new treatment modality for polycystic ovary syndrome?
- M. Schlaich, N. Straznicky, P. Sobotka
- Medicine, BiologyJournal of Hypertension
- 1 May 2011
Findings corroborate the relevance of sympathetic activation in PCOS and suggest that renal denervation exerts beneficial effects not only on blood pressure control but also on insulin sensitivity, renal, and endocrine abnormalities characteristic of PCOS.
The neuronal noradrenaline transporter, anxiety and cardiovascular disease
- M. Esler, M. Alvarenga, G. Lambert
- Biology, PsychologyJournal of Psychopharmacology
- 1 July 2006
It is suspected that this phenotype of impaired neuronal reuptake of noradrenaline, in sensitizing people to heart symptom development, is a cause of panic disorder, and by magnifying the sympathetic neural signal in the heart, underlies increased cardiac risk.
Renalase, a novel soluble FAD-dependent protein, is synthesized in the brain and peripheral nerves
- S. Hennebry, N. Eikelis, F. Socratous, G. Desir, G. Lambert, M. Schlaich
- BiologyMolecular Psychiatry
- 1 March 2010
Renalase, a novel soluble FAD-dependent protein, is synthesized in the brain and peripheral nerves and shown to act as a ‘spatially aggregating force’ in the cell.
[Rilmenidine sympatholytic activity preserves mental and orthostatic sympathetic response and epinephrine secretion].
- M. Esler, A. Lux, G. Jennings, J. Hastings, F. Socratous, G. Lambert
- Medicine, BiologyArchives des maladies du coeur et des vaisseaux
- 1 March 2003
Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion
- M. Esler, A. Lux, G. Jennings, J. Hastings, F. Socratous, G. Lambert
- Medicine, BiologyJournal of Hypertension
- 1 August 2004
The present study confirms a sympatholytic effect of rilmenidine during supine rest but preservation of sympathetic responses during mental stress and tilting, with the latter underlying a freedom from postural hypotension on the drug.
...
...