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Sympathetic activation in chronic renal failure.
TLDR
Analysis of potential mechanisms underlying sympathetic activation in chronic kidney disease, the range of adverse consequences associated with this activation, and potential therapeutic implications resulting from this relationship are analyzed.
Relation Between Cardiac Sympathetic Activity and Hypertensive Left Ventricular Hypertrophy
TLDR
It is demonstrated that hypertensive LV hypertrophy is associated with increased sympathetic activity largely confined to the heart, suggesting that increased cardiac norepinephrine release is related to the development of LVhypertrophy.
Sympathetic Nerve Biology In Essential Hypertension
TLDR
A key piece of evidence supporting the neurogenic basis of essential hypertension is shown, in addition to the obvious one of an increased rate of sympathetic nerve firing, of the increased spillover of noradrenaline from the kidneys and heart to plasma.
Altered Sympathetic Nervous Reactivity and Norepinephrine Transporter Expression in Patients With Postural Tachycardia Syndrome
TLDR
Patients with POTS exhibit a decrease in NET protein in their peripheral sympathetic nerves, and whole-body NE spillover to plasma during rest in the supine position and in response to head-up tilt is not altered despite excessive nerve firing rate.
The neuronal noradrenaline transporter, anxiety and cardiovascular disease
TLDR
It is suspected that this phenotype of impaired neuronal reuptake of noradrenaline, in sensitizing people to heart symptom development, is a cause of panic disorder, and by magnifying the sympathetic neural signal in the heart, underlies increased cardiac risk.
Renal denervation: a potential new treatment modality for polycystic ovary syndrome?
TLDR
Findings corroborate the relevance of sympathetic activation in PCOS and suggest that renal denervation exerts beneficial effects not only on blood pressure control but also on insulin sensitivity, renal, and endocrine abnormalities characteristic of PCOS.
Renalase, a novel soluble FAD-dependent protein, is synthesized in the brain and peripheral nerves
TLDR
Renalase, a novel soluble FAD-dependent protein, is synthesized in the brain and peripheral nerves and shown to act as a ‘spatially aggregating force’ in the cell.
Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion
TLDR
The present study confirms a sympatholytic effect of rilmenidine during supine rest but preservation of sympathetic responses during mental stress and tilting, with the latter underlying a freedom from postural hypotension on the drug.
[Rilmenidine sympatholytic activity preserves mental and orthostatic sympathetic response and epinephrine secretion].
TLDR
This study confirms a sympatholytic effect of rilmenidine during supine rest but demonstrates that sympathetic responses during mental stress and tilting are preserved, the latter underlying a perhaps surprising absence of postural hypotension on the drug.
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