Share This Author
Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2
It is concluded that this transcript is the physiologically most important substrate of ADAR2, as it specifies an ion channel determinant, the Q/R site, in AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor GluR-B pre-messenger RNA.
RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency
Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus
- B. Niewoehner, F. Single, D. Bannerman
- Biology, PsychologyThe European journal of neuroscience
- 1 February 2007
The present results show that dissociations between spatial working memory and spatial reference memory can be induced by disrupting synaptic plasticity specifically and exclusively within the dentate gyrus subfield of the hippocampal formation.
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy
- H. Tan, C. Reid, S. Petrou
- Biology, PsychologyProceedings of the National Academy of Sciences
- 30 October 2007
A mouse model harboring a γ2 subunit point mutation (R43Q) found in a large Australian family demonstrated behavioral arrest associated with 6-to 7-Hz spike-and-wave discharges, which are blocked by ethosuximide, a first-line treatment for absence epilepsy in man.
Dysfunctions in Mice by NMDA Receptor Point Mutations NR1(N598Q) and NR1(N598R)
Analysis of the key properties of NMDA receptors, high Ca2+ permeability, and voltage-dependent Mg2+ block, in the mutant mice indicates that properties controlled by NR1 subunit residue N598 are important for autonomic brain functions at birth and during postnatal development.
Developmental impact of a familial GABAA receptor epilepsy mutation
This data indicates that introduction of this GABAA γ2 gene mutation into a mouse by gene targeting recapitulates the human phenotype demonstrating a strong genotype to phenotype link.
Impaired synaptic scaling in mouse hippocampal neurones expressing NMDA receptors with reduced calcium permeability
- V. Pawlak, Bettina J. Schupp, F. Single, P. Seeburg, G. Köhr
- BiologyThe Journal of physiology
- 1 February 2005
The results indicate that NMDAR‐mediated Ca2+ signalling is important for synaptic scaling of AMPA currents in the hippocampus in vivo.
Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse
Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons.
The results suggest that NMDA receptors and GluR-B containing AMPA receptors are not essential for fertility, but that Glu R-Bcontaining AMPA receptor are essential for male and female reproduction-related behaviors, perhaps by mediating responses to pheromones or odorants.
Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies
The capability to regulate knock-down strength may spark a new approach for the functional study of membrane and plasma proteins, which may especially be valuable for generating mouse models that more closely resemble disease states than classic knockouts do.