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Gene structure, intracellular localization, and functional roles of sterol carrier protein-2.
TLDR
Although the 13 kDa SCP-2 is the most studied of these proteins, because it exhibits diversity of its ligand partners, new potential physiological function(s) are still being proposed and questions regarding potential compensation by other proteins with overlapping specificity are only beginning to be resolved. Expand
Peroxisome Proliferator-activated Receptor α Interacts with High Affinity and Is Conformationally Responsive to Endogenous Ligands*
TLDR
The finding that saturated fatty acyl-CoAs, rather than saturated fatty acids, are high affinity PPARα ligands provides a mechanism accounting for saturated fatty acid transactivation in cell-based assays. Expand
Cellular uptake and intracellular trafficking of long chain fatty acids.
TLDR
The emerging picture is that the cell has multiple, overlapping mechanisms that assure adequate uptake and directed intracellular movement of LCFA required for maintenance of physiological functions. Expand
Role of Fatty Acid Binding Proteins and Long Chain Fatty Acids in Modulating Nuclear Receptors and Gene Transcription
TLDR
The hypothesis that cytoplasmic lipid binding proteins transfer and channel lipidic ligands into nuclei for initiating nuclear receptor transcriptional activity to provide new lipid nutrient signaling pathways that affect lipid and glucose catabolism and storage is proposed. Expand
Liver fatty acid-binding protein and obesity.
TLDR
Data suggest that L-FABP could have an important role in preventing age- or diet-induced obesity and in reducing hepatic LCFA uptake/oxidation and increasing LCFAs available for oxidation in muscle and/or storage in adipose. Expand
Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate
TLDR
These findings, complemented by the good tolerability and low toxicity to mammals, suggest that AAD 1566, monepantel, would be a suitable anthelmintic drug development candidate. Expand
L-FABP directly interacts with PPAR&agr; in cultured primary hepatocytes
TLDR
In vitro and imaging experiments demonstrate high affinity, structural molecular interaction of L-FABP with PPAR&agr; and suggest a functional role for L- FABP interaction with PPARI; in long chain fatty acid (LCFA) metabolism. Expand
Decreased Liver Fatty Acid Binding Capacity and Altered Liver Lipid Distribution in Mice Lacking the Liver Fatty Acid-binding Protein Gene*
TLDR
A quantitative assessment of the contribution of L-FABP to cytosolic fatty acid binding capacity is provided and it is suggested that SCP-2 contributes to the accumulation of cholesterol in L- FABP null liver. Expand
Amyloid β‐Peptides Increase Annular and Bulk Fluidity and Induce Lipid Peroxidation in Brain Synaptic Plasma Membranes
TLDR
Aβ‐induced changes in neuronal function, such as ion flux and enzyme activity, that have been reported previously may result from the combined effects of lipid peroxidation and increased membrane fluidity. Expand
Steroidogenic Acute Regulatory Protein Binds Cholesterol and Modulates Mitochondrial Membrane Sterol Domain Dynamics*
TLDR
StAR is a cholesterol-binding protein, preferentially enhances sterol transfer from steroidogenic cell mitochondria, and interacts with mitochondrial membranes to alter their sterol domain structure and dynamics. Expand
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