Skip to search formSkip to main contentSkip to account menu

The Janus face of HMGB1 in heart disease: a necessary update

TLDR
High mobility group box 1 elicits both harmful and beneficial responses that may in part depend on the generation and stability of the diverse redox forms, whose specific functions in this context remain mostly unexplored.
View on Springer (opens in a new tab)

Phoenixin-14: detection and novel physiological implications in cardiac modulation and cardioprotection

TLDR
The data provide a first evidence on the peripheral activity of PNX and on its direct cardiomodulatory and cardioprotective role under both normal conditions and in the presence of metabolic disorders.
View on Springer (opens in a new tab)

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

TLDR
It is suggested that selected humoral fluid-phase PRMs can play an important role in resistance to, and pathogenesis of, COVID-19, a finding with translational implications.
View on Springer (opens in a new tab)

The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification

TLDR
The vascular age-associated miR-34a promotes VSMCs SASP activation and contributes to arterial inflammation and dysfunctions such as VC.
View PDF (opens in a new tab)

Protective Role of GPER Agonist G‐1 on Cardiotoxicity Induced by Doxorubicin

TLDR
It is suggested that GPER activation mitigates Dox‐induced cardiotoxicity, thus proposing GPER as a novel pharmacological target to limit the detrimental cardiac effects of Dox treatment.
View on Wiley (opens in a new tab)

Chromofungin, CgA47-66-derived peptide, produces basal cardiac effects and postconditioning cardioprotective action during ischemia/reperfusion injury

View on Elsevier (opens in a new tab)

The NO stimulator, Catestatin, improves the Frank-Starling response in normotensive and hypertensive rat hearts.

View on PubMed (opens in a new tab)

Leopoldia comosa prevents metabolic disorders in rats with high-fat diet-induced obesity

TLDR
In vivo data showed that the supplementation with both doses of L. comosa extracts counteracted the HFD-dependent effects, which paves the way for their therapeutic application as a natural anti-obesity drug.
View on Springer (opens in a new tab)

Physiological levels of chromogranin A prevent doxorubicin‐induced cardiotoxicity without impairing its anticancer activity

TLDR
Investigation of chromogranin A (CgA), a cardioregulatory protein released in the blood by the neuroendocrine system and by the heart itself, may contribute to regulation of the cardiotoxic and antitumor activities of doxorubicin (Doxo), suggesting that administration of low‐dose CgA to patients with low levels of endogenous C gA might represent a novel approach to prevent Doxo‐induced adverse events.
View on Wiley (opens in a new tab)

Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging

TLDR
In a healthy population cRAGE is a biomarker of aging while esRAGE represents a more reliable marker of obesity and insulin resistance, Hence, sRAGE isoforms levels could be differentially associated with age-related diseases risk factors.
View PDF (opens in a new tab)
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)