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Bromopyrrole Alkaloids as Lead Compounds against Protozoan Parasites
Results indicate longamide B and dibromopalau’amine (11) to be promising trypanocidal and antileishmanial agents, while dispacamide B (3) and spongiacidin B (6) emerge as antimalarial lead compounds.
Cannabimovone, a Cannabinoid with a Rearranged Terpenoid Skeleton from Hemp
The biological profile of anhydrocannabimovone was somewhat similar to that of THC (4), suggesting a remarkable tolerance to constitutional and configurational changes.
Manadoperoxides A-D from the Indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials.
The new endoperoxyketal polyketides manadoperoxides A-D (2-5) have been isolated from the Indonesian sponge Plakortis cfr. simplex and their stereostructures established by means of spectroscopic
Cannabioxepane, a Novel Tetracyclic Cannabinoid from Hemp, Cannabis sativa L.
Theolate and structure elucidation of cannabioxepane (I), which does not show cannabinoid activity, and isocannabispiradienone (II) shows cannabinoid activity.
Insight into the mechanism of action of plakortins, simple 1,2-dioxane antimalarials.
The results show that these molecules, after interaction of the endoperoxide bond with Fe(ii), likely coming from the heme molecule, give rise to the formation of an oxygen radical, followed by rearrangement to give a carbon radical centered on the "western" alkyl side-chain.
Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin.
Interestingly, it appears that minor structural changes, such as a shift of the methyl group around the dioxane ring, can dramatically affect the antitrypanosomal activity.
Dehydroconicasterol and aurantoic acid, a chlorinated polyene derivative, from the Indonesian sponge Theonella swinhoei.
The chlorinated polyene aurantoic acid (1) and the 4-methylene sterol dehydroconicasterol (2) were isolated from the Indonesian sponge Theonella swinhoei, and their structures were elucidated by
Magnetic-Resonance-Imaging Texture Analysis Predicts Early Progression in Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiation
The results suggest that texture analysis from the preoperative MRI could be useful to identify patients that may develop early progression, and the model was validated based on the prediction accuracy calculated in a previously unseen set of 15 patients.