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Antifibromyalgic activity of standardized extracts of Phyllanthus amarus and Phyllanthus fraternus in acidic saline induced chronic muscle pain
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Design and development of liquisolid compact of candesartan cilexetil to enhance dissolution
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Pharmacological characterization of carrageenan induced heat muscle hyperalgesia in rats using non-selective, preferential and selective COX-2 inhibitors.
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Molecular Docking Studies of Phytocompounds from the Phyllanthus Species as Potential Chronic Pain Modulators
TLDR
The docking scores and analysis of the interactions of the phytocompounds with target proteins suggest that important molecules like lupeol, phyllanthin, hypopyllanth in, corilagin, epicatechin, and most of the other compounds have the ability to bind to multiple targets involved in inflammatory hyperalgesia.
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Formation of Amorphous Telmisartan Polymeric Microparticles for Improvement of Physicochemical Characteristics
In order to improve solubility and dissolution rate of poorly aqueous soluble telmisartan, its amorphous polymeric microparticles with PVP K30 were prepared with or without aid of adsorbent…
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Isolation, Characterization and Evaluation of Ocimum Basilicum Seed Mucilage for Tableting Performance
TLDR
It is possible to conclude that Ocimum basilicum seed mucilage could be used in direct compression with other excipients and in wet granulation technology as a superdisintegrant.
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Preparation of amorphous carvedilol polymeric microparticles for improvement of physicochemical properties
The aim of the present study was to enhance the physicochemical properties of poorly aqueous soluble carvedilol (CRV) by preparing its microparticles in presence and/or in absence of a hydrophilic…
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Membrane Stabilizing Activity and Protein Denaturation : A Possible Mechanism of Action for the Anti-Inflammatory Activity of Phyllanthus amarus
TLDR
It can be postulated from the observed results that the anti-inflammatory activity of Phyllanthus amarus could be due to its membrane stabilizing action and inhibition of protein denaturation.
Pharmacognostic, Physicochemical and Phytochemical Investigation of Root Bark of Caesalpinia bonducella
TLDR
Investigation of root bark of Caesalpinia bonducella revealed the presence of cork, cortex, stone cell medullary ray’s calcium oxalate crystal, starch grains, presence of tannins and alkaloids, and preliminary phytochemical screening revealed that presence of alkaloid, saponins, flavonoids, steroids, phytosterols and carbohydrates in aqueous and ethanol extracts.
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Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia
TLDR
It is strongly suggested that the observed antihyperalgesic and antiinflammatory effects of P. amarus in current pain model are mediated via spinal or supraspinal neuronal mechanisms, mainly by inhibition of PGE2.
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