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Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment
The association of chemotherapeutic agents with lipid nanoparticles reduces active therapeutic dose and toxicity, decreases drug resistance and increases drug levels in tumor tissue by decreasing them in healthy tissue.
Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells†
A library of epothilone A and B analogues, which was constructed by solid-phase combinatorial synthesis using SMART Microreactors and solution chemistry, was screened in two different tubulin binding assays and important structure–activity relationship emerged.
Chemistry and biology of cyclic depsipeptides of medicinal and biological interest.
- F. Sarabia, S. Chammaa, A. Ruiz, L. M. Ortiz, F. J. L. Herrera
- Biology, ChemistryCurrent medicinal chemistry
- 1 May 2004
The present review deals with the most interesting aspects of the biology and the chemistry of some of the cyclic depsipeptides.
Emerging pollutants in the Esmeraldas watershed in Ecuador: discharge and attenuation of emerging organic pollutants along the San Pedro-Guayllabamba-Esmeraldas rivers.
- A. Voloshenko-Rossin, G. Gasser, O. Lev
- Environmental ScienceEnvironmental science. Processes & impacts
The research provides a way to compare drug consumption in a major Latin American city (Quito) and shows that the consumption of most sampled drugs was below their average consumption level in Europe, Israel, and North America.
Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ.
- Gabriella Nepomuceno, Katie M. Chan, J. Shaw
- Biology, ChemistryACS medicinal chemistry letters
- 21 January 2015
Synthesis of analogues that contain a more tractable core structure and an analogue with single-digit micromolar inhibition of FtsZ's GTPase activity, which represents the most potent inhibitor of Escherichia coli Fts Z reported to date are reported.
Total synthesis of 26-hydroxy-epothilone B and related analogs via a macrolactonization based strategy
2‐Azido‐2‐deoxycellulose: Synthesis and 1,3‐Dipolar Cycloaddition
Chitosan (1) was prepared by basic hydrolysis of chitin of an average molecular weight of 70000 Da, 1H-NMR spectra indicating almost complete deacetylation. N-Phthaloylation of 1 yielded the known…
Synthesis of epothilones A and B in solid and solution phase
The solid-phase synthesis applied here to epothilone A could open up new possibilities in natural-product synthesis and paves the way for the generation of large combinatorial libraries of these important molecules for biological screening.
The Olefin Metathesis Approach to Epothilone A and Its Analogues
The olefin metathesis approach to epothilone A (1) and several analogues (39−41, 42−44, 51−57, 58−60, 64−65, and 67−69) is described. Key building blocks 6−8 were constructed in optically active form…
Tripalmitin nanoparticle formulations significantly enhance paclitaxel antitumor activity against breast and lung cancer cells in vitro
A new PTX nanoformulation based on the use of tripalmitin which improves the antitumor activity of PTX and that may serve as an alternative PTX delivery system in breast and lung cancer treatment is offered.