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The nucleotide sequence for a proline-activating domain of gramicidin S synthetase 2 gene from Bacillus brevis.
A fragment encoding proline-activating domain (grs 2-pro) of gramicidin S synthetase 2 (GS 2) was found in an 8.1-kilobase pairs (kb) DNA fragment of Bacillus brevis Nagano, which contained the fullExpand
Entire nucleotide sequence for Bacillus brevis Nagano Grs2 gene encoding gramicidin S synthetase 2: a multifunctional peptide synthetase.
TLDR
Results indicated that the repeated and conserved domains are the individual activation sites of the constituent amino acids; the activation sites are arranged in the order of peptide elongation on GS2. Expand
Synthesis of Pseudodeflectusin and Ustusorane C: Structural Revision of Aspergione A and B
TLDR
The results confirm that aspergione A and B are in fact ustusorane C and pseudodeflectusin, respectively. Expand
Mutant genes of gramicidin S synthetase 1 defective in phenylalanine racemization have the same sequence as the wild gene.
Mutant grs1 genes were cloned and sequenced from the Bacillus brevis Nagano BI-4, C-3, E-1, and E-2 strains, which produce defective gramicidin S synthetase 1 (GS1), lacking racemase activity.Expand
Synthesis and Absolute Configuration of (+)‐Pseudodeflectusin: Structural Revision of Aspergione B
We report herein the total synthesis and determination of the absolute configuration of (+)-pseudodeflectusin. The total synthesis of (+)-pseudodeflectusin starting from o-anisic aid was achieved inExpand
Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases.
We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases alpha and beta, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and theExpand
Synthesis of plakevulin A and structure–activity relationships of its related compounds against DNA polymerases
Abstract Synthesis of plakevulin A and structure–activity relationships of its related compounds against DNA polymerases is described. We have achieved a total synthesis and revised the structure ofExpand
Synthesis of the proposed structure of plakevulin A: revised structure of plakevulin A
Abstract A total synthesis of the proposed structure of plakevulin A was accomplished. However, the NMR spectral data of the synthetic plakevulin A were not identical of those of the reportedExpand
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