F. Sagami

Publications90
h-index14
Citations608
Highly Influential Citations18
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Collaborative work on evaluation of ovarian toxicity by repeated-dose and fertility studies in female rats.
TLDR
A validation study intended to evaluate whether a 2-week repeated general toxicity period with histopathological examination is sufficient to detect ovarian toxicity found that it may be sufficient, except for cytotoxic compounds such as alkylating agents.
In vivo genotoxicity and DNA adduct levels in the liver of rats treated with safrole.
TLDR
The results show that safrole is a genotoxic carcinogen in the rat liver in vivo and suggest that the cytogenetic effects of this compound may result from covalent DNA modification in theRat liver, and a useful means of evaluation of the genotoxicity of hepatocarcinogens.
[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration].
TLDR
The No Observed Adverse Effect Level (NOAEL) for general toxicity of dams and embryo-fetal development was 0.3 mmol/kg/day, and that of mated NZW female rabbits treated with Gadobenate dimeglumine (E7155) caused initial, notable loss of body weight and reduction in food consumption.
Mutagenicity of dihydroxybenzenes and dihydroxynaphthalenes for Ames Salmonella tester strains.
Current opinion: safety evaluation of drug metabolites in development of pharmaceuticals.
Safety assessment of drug metabolites in the development of pharmaceuticals was discussed in January 2007 at the kick-off meeting of a "Drug Evaluation Forum", with reference to the views of…
Use of human liver S9 in the Ames test: assay of three procarcinogens using human S9 derived from multiple donors.
Comparison of the mutational spectra of the lacZ transgene in four organs of the MutaMouse treated with benzo[a]pyrene: target organ specificity.
Multiple organ mutation in the lacZ transgenic mouse (Muta mouse) 6 months after oral treatment (5 days) with benzo[a]pyrene.
The unique feature of dog liver cytosolic glutathione S-transferases. An isozyme not retained on the affinity column has the highest activity toward 1,2-dichloro-4-nitrobenzene.
Decrease in the specific forms of cytochrome P-450 in liver microsomes of a mutant strain of rat with hyperbilirubinuria.
TLDR
Results indicated the form-specific alteration in the amounts of cytochrome P-450 in liver microsomes of EHBR.
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