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In Vitro Activities of Posaconazole, Fluconazole, Itraconazole, Voriconazole, and Amphotericin B against a Large Collection of Clinically Important Molds and Yeasts
TLDR
Posaconazole exhibited potent antifungal activity against a wide variety of clinically important fungal pathogens and was frequently more active than other azoles and amphotericin B.
Application of Real-Time Quantitative PCR to Molecular Analysis of Candida albicans Strains Exhibiting Reduced Susceptibility to Azoles
TLDR
Despite both the increases in pump expression and the ERG11 mutations, only one of the patient isolates exhibited a large decrease in posaconazole susceptibility.
The most frequent aminoglycoside resistance mechanisms--changes with time and geographic area: a reflection of aminoglycoside usage patterns? Aminoglycoside Resistance Study Groups.
The aminoglycoside resistance mechanisms revealed by two surveys in Europe and other countries have been compared to those revealed in earlier studies. Mechanisms have become more complex in all
The most frequently occurring aminoglycoside resistance mechanisms--combined results of surveys in eight regions of the world. The Aminoglycoside Resistance Study Groups.
TLDR
The most common resistance mechanisms in the seven different pathogen groups were summarised and the greatest diversity of resistance mechanisms (67 in 1189 isolates) was found in Acinetobacter, where the most common mechanisms - APH(3')-VI and AAC(3)-? - were generally very rare in other genera but found frequently in Acnetobacter in combinations with a wide variety of other mechanisms.
Comparison of aminoglycoside resistance patterns in Japan, Formosa, and Korea, Chile, and the United States
TLDR
Differences in the frequencies of resistance to gentamicin, tobramycin, dibekacin, and amikacin in strains from the United States were different from those in strain from the Far East, correlated with different aminoglycoside usage in the two regions.
Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens
TLDR
High-pressure liquid chromatographic analysis of extracts prepared from Escherichia coli carrying the chromosomal aac(6')-Ic gene on a plasmid confirmed the presence of 6'-N-acetyltransferase activity in this strain, which was suggested by the aminoglycoside resistance profile.
Correlation between aminoglycoside resistance profiles and DNA hybridization of clinical isolates
TLDR
DNA hybridization revealed interesting differences in the frequencies of these genes by organism and by country, and showed that individual strains carried up to six unique aminoglycoside resistance genes.
The changing nature of aminoglycoside resistance mechanisms and the role of isepamicin--a new broad-spectrum aminoglycoside. The Aminoglycoside Resistance Study Groups.
TLDR
Aminoglycoside resistance mechanisms from recent studies were compared with those found in earlier studies in the USA and Europe for three pathogen groups and different genes which produce different proteins with the same aminoglycosid-modifying activity are now known are presented.
In vitro Gram-positive antimicrobial activity of evernimicin (SCH 27899), a novel oligosaccharide, compared with other antimicrobials: a multicentre international trial.
TLDR
The results of this in vitro, multicentre, multinational study demonstrate that evernimicin possesses high antimicrobial activity against Gram-positive organisms that compares favourably with established antibacterial treatments and newer agents such as quinupristin/dalfopristin.
Evaluation of netilmicin susceptibility discs using bacteria with known aminoglycoside resistance patterns: correlation of in vitro and in vivo test results.
TLDR
The good correlation between disc sensitivity test results and MIC and PD50 values suggest that a 30 micrograms netilmicin disc can be used to predict the netILmicin susceptibility of clinical isolates.
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