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Nature of the main contaminant in the anti malaria drug primaquine diphosphate: a qualitative isomer analysis.
TLDR
It is suggested that minor amount of other related substances can contribute more to the toxicity of the drug primaquine diphosphate than the positional isomer quinocide. Expand
Inhibition of nitric oxide-dependent activation of soluble guanylyl cyclase by the antimalarial drug, artemisinin.
TLDR
Inhibition of guanylyl cyclase activation by NO donors but not by protoporphyrin 1X represents a possible additional mechanism of the pharmacological action of this drug. Expand
Synthesis of Naphthyridines
A method for the preparation of 2,3,9,10-tetrahydro[1,4]benzodioxino[6,7-h][1,6]naphthyridin-4(1H)-one by cyclization of 2,3-dihydro-9-[(2-carboxyethyl)amino][1,4]dioxino[2,3-g]quinoline-8-carboxylicExpand
[The search for new antiparasitic agents. 10. The synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the
TLDR
One of the derivatives of benzo(g)quinoline, named QUINOPRAZINE, showed some action against Plasmodium berghei chloroquine--resistant infection (isolate LN-K65) and was elected for further tests. Expand
Synthesis of tricylic systems incorporating the azepine ring
Some tricyclic compounds (derivatives of pyrazino[2,1-a]benzazepine, diazepino[7,1-a]isoquinoline, and some pyrimido[6,1-a]isoquinolines) which are analogs of the anthelmintic praziquantel have beenExpand
[The search for new antiparasitic agents. 12. The synthesis and study of the anti-Echinococcus and anti-Hymenolepis activity of 6-[4-(4-alkylpiperazinyl-1)-phenylamino]-1,2,5-thiadazolo[3 ,4-h]
TLDR
Drug G-1574 has been demonstrated to ensure 100% recovery of spontaneously Hymenolepis nana-infected albino mice given doses 2.5-5 times lower than the effective dose of phenasal (niclosamide). Expand
[The search for new antiparasitic agents. 8. The synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines].
TLDR
These compounds were found to be able to suppress the growth of larvocysts of Echinococcus multilocularis in cotton rats when injected intraperitoneally in a single dose of 0.25 g/kg, close to capacity of mebendazole. Expand
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