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Biological properties of extracellular vesicles and their physiological functions
TLDR
A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. Expand
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
TLDR
Findings identify hnRNPA2B1 as a key player in miRNA sorting into exosomes and provide potential tools for the packaging of selected regulatory RNAs into exOSomes and their use in biomedical applications. Expand
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.
TLDR
In vitro adhesion assay on tissue sections found that lymphocytes and monocytes bound selectively to inflamed EAE brain vessels, and therapies designed to interfere with alpha 4 beta 1 integrin may be useful in treating inflammatory diseases of the central nervous system, such as multiple sclerosis. Expand
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
TLDR
It is shown that exosomes of T, B and dendritic immune cells contain microRNA (miRNA) repertoires that differ from those of their parent cells, and that miRNAs transferred during immune synapsis are able to modulate gene expression in recipient cells. Expand
Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes
TLDR
The results provide the first characterization of an endothelial docking structure that plays a key role in the firm adhesion of leukocytes to the endothelium during inflammation. Expand
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
TLDR
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles that aims to provide a single authoritative source for information on vesicle structure and function. Expand
Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes.
TLDR
Modulation by tetraspanins of the function of adhesion receptors involved in inflammation, lymphocyte activation, cancer and pathogen infection suggests potential as therapeutic targets and implications for cell adhesion, proteolysis and pathogenesis are discussed. Expand
Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells.
TLDR
The results suggest that mesothelial cells have an active role in the structural and functional alteration of the peritoneum during peritoneal dialysis, and suggest potential targets for the design of new dialysis solutions and markers for the monitoring of patients. Expand
Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation
TLDR
It is shown that ligand engagement of TCR-CD3 induces a conformational change that exposes a proline-rich sequence in CD3 epsilon and results in recruitment of the adaptor protein Nck, which is critical for maturation of the immune synapse and for T cell activation. Expand
CD69 is an immunoregulatory molecule induced following activation.
TLDR
Recent studies in CD69-deficient mice have revealed a non-redundant role for this receptor in downregulation of the immune response through the production of the pleiotropic cytokine transforming growth factor-β (TGF-β). Expand
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