F. Rutjes

Publications493
h-index52
Citations11,347
Highly Influential Citations71
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Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells**
TLDR
Symmetrical BCN derivatives display excellent reaction kinetics in strain-promotedcycloaddition reactions and were applied in the labeling of proteins and glycans, as well as in the three-dimensional visualization of living melanomacells.
Bioconjugation with strained alkenes and alkynes.
TLDR
Progress in bioconjugation centered around cycloadditions of cyclic alkenes and alkynes have now established themselves as powerful tools in reagent-freeBioconjugations.
Aza-Dibenzocyclooctynes for Fast and Efficient Enzyme PEGylation via Copper-Free [3 + 2] Cycloaddition.
Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitro.
TLDR
Data indicate that it is unlikely that methyl groups at the guanidino position of peptidylarginine can be removed by peptIDylcitrulline deiminases, which has important implications for the recently reported role of these enzymes in gene regulation.
Azide: A Unique Dipole for Metal‐Free Bioorthogonal Ligations
TLDR
The potential of azides to undergo metal‐free reactions with strained unsaturated systems has inspired the development of an increasing number of reactive probes, which are comprehensively summarized here.
Peptide-mediated blood-brain barrier transport of polymersomes.
TLDR
The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.
Polymersome colloidosomes for enzyme catalysis in a biphasic system.
Bioorthogonal labelling of biomolecules: new functional handles and ligation methods.
This review provides a literature overview of bioorthogonal ligation methods for protein modification, which have largely evolved over the last 15 years. Since 1990, various new reactions have been…
Toward nanomolar detection by NMR through SABRE hyperpolarization.
TLDR
The efficiency of SABRE at low substrate concentrations can be restored by addition of a suitable coordinating ligand to the solution by showing that the method allowed NMR detection below 1 μM in a single scan.
Ligand effects of NHC-iridium catalysts for signal amplification by reversible exchange (SABRE).
SABRE hyperpolarizes substrates by polarization transfer from para-hydrogen in a metal complex. We have measured the signal enhancement of pyridine and its exchange rate in various…
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