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- Publications
- Influence
Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitro.
- R. Raijmakers, A. J. W. Zendman, +7 authors G. Pruijn
- Chemistry, Medicine
- Journal of molecular biology
- 6 April 2007
Peptidylarginine deiminase (PAD) enzymes catalyze the conversion of arginine residues in proteins to citrulline residues. Citrulline is a non-standard amino acid that is not incorporated in proteins… Expand
Aza-Dibenzocyclooctynes for Fast and Efficient Enzyme PEGylation via Copper-Free [3 + 2] Cycloaddition.
- M. F. Debets, S. V. Berkel, Sanne Schoffelen, F. Rutjes, J. V. Hest, F. L. V. Delft
- Chemistry
- 1 June 2010
Azide: A Unique Dipole for Metal‐Free Bioorthogonal Ligations
- M. F. Debets, Christianus W J van der Doelen, F. Rutjes, F. V. van Delft
- Chemistry, Medicine
- Chembiochem : a European journal of chemical…
- 14 June 2010
Covalently bound azide on a (small) organic molecule or a (large) biomolecular structure has proven an important handle for bioconjugation. Azides are readily introduced, small, and stable, yet… Expand
Bioorthogonal labelling of biomolecules: new functional handles and ligation methods.
- M. F. Debets, J. V. van Hest, F. Rutjes
- Medicine, Chemistry
- Organic & biomolecular chemistry
- 13 September 2013
This review provides a literature overview of bioorthogonal ligation methods for protein modification, which have largely evolved over the last 15 years. Since 1990, various new reactions have been… Expand
Synthesis of non-natural carbohydrates from glycerol and aldehydes in a one-pot four-enzyme cascade reaction
- Lara Babich, C. HemertvanJ., +6 authors F. Rutjes
- Chemistry, Engineering
- 10 January 2011
A simple procedure has been developed for the synthesis of enantio- and diastereomerically pure carbohydrate analogues from glycerol and a variety of aldehydes in one pot using a four-enzyme cascade… Expand
Metal‐Free Triazole Formation as a Tool for Bioconjugation
- Sander S. van Berkel, A. Dirks, +4 authors F. Rutjes
- Chemistry, Medicine
- Chembiochem : a European journal of chemical…
- 3 September 2007
The development of selective and site-specific bio-orthogonal conjugation methods is an important topic in chemical biology. A wide range of methods, such as the Staudinger ligation, native chemical… Expand
Polymersome colloidosomes for enzyme catalysis in a biphasic system.
- Zhipeng A. Wang, Matthijs C M van Oers, F. Rutjes, J. V. van Hest
- Chemistry, Medicine
- Angewandte Chemie
- 22 October 2012
Conjugation of nucleosides and oligonucleotides by [3+2] cycloaddition.
- Anup M. Jawalekar, N. Meeuwenoord, +4 authors F. V. van Delft
- Chemistry, Medicine
- The Journal of organic chemistry
- 4 January 2008
A procedure is presented for copper(I)-catalyzed [3+2] cycloaddition of nucleosides and nucleotides in near-quantitative yield. Azido-alkyne cycloaddition was applied for the preparation of a range… Expand
Preparation of biohybrid amphiphiles via the copper catalysed Huisgen [3 + 2] dipolar cycloaddition reaction.
- A. Dirks, Sander S. van Berkel, +7 authors R. J. Nolte
- Chemistry, Medicine
- Chemical communications
- 12 August 2005
Biohybrid amphiphiles have been prepared from terminal azide functionalised polystyrene and an alkyne functionalised peptide or protein via a Cu(I) catalysed Huisgen [3 + 2] dipolar cycloaddition… Expand
Application of Metal‐Free Triazole Formation in the Synthesis of Cyclic RGD–DTPA Conjugates
- Sander S. van Berkel, A. Dirks, +6 authors F. Rutjes
- Chemistry, Medicine
- Chembiochem : a European journal of chemical…
- 21 July 2008
The tandem 1,3‐dipolar cycloaddition‐retro‐Diels–Alder (tandem crDA) reaction is presented as a versatile method for metal‐free chemoselective conjugation of a DTPA radiolabel to… Expand