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The human heart endothelin system: ET-1 synthesis, storage, release and effect.
Endothelin-1 (ET-1) is synthesized, stored and released in the human heart. On release, ET-1 has the potential to activate specific receptors in a paracrine manner to modify heart function directly.… Expand
Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids
Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) are recommended for management of patients with wide-ranging chronic diseases, including coronary heart disease, rheumatoid arthritis,… Expand
Human endothelial cell storage granules: a novel intracellular site for isoforms of the endothelin-converting enzyme.
We have previously shown endothelin (ET)-like immunoreactive staining in Weibel-Palade bodies, storage granules that are an integral component of the regulated secretory pathway in endothelial cells.… Expand
Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure.
- F. Russell, D. Meyers, +4 authors P. Molenaar
- American journal of physiology. Heart and…
- 1 October 2003
Human urotensin-II (hU-II) is the most potent endogenous cardiostimulant identified to date. We therefore determined whether hU-II has a possible pathological role by investigating its levels in… Expand
(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the β1-adrenoceptor
- D. Sarsero, F. Russell, +6 authors P. Molenaar
- Naunyn-Schmiedeberg's Archives of Pharmacology
Abstract. Two forms of the activated β1-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial… Expand
Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart.
OBJECTIVE This study investigated signaling pathways that may contribute to the potent positive inotropic effect of human urotensin-II (hU-II) in human isolated right atrial trabeculae obtained from… Expand
Cardiostimulant effects of urotensin‐II in human heart in vitro
The effects of the recently identified human peptide urotensin‐II (hU‐II) were investigated on human cardiac muscle contractility and coronary artery tone. In right atrial trabeculae from non‐failing… Expand
Emerging roles of urotensin-II in cardiovascular disease.
- F. Russell
- Biology, Medicine
- Pharmacology & therapeutics
- 1 September 2004
Urotensin-II (UII) is a highly potent endogenous peptide within the cardiovascular system. Through stimulation of Galphaq-coupled UT receptors, UII mediates contraction of vascular smooth muscle and… Expand
Characterization and localization of atypical β‐adrenoceptors in rat ileum
1 . Homogenate binding studies and receptor autoradiography have been used to examine the binding characteristics and localization of propranolol‐resistant (—)‐[125I]‐cyanopindolol (CYP) binding… Expand