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Walking along the rabies genome: is the large G-L intergenic region a remnant gene?
- N. Tordo, O. Poch, A. Ermine, G. Keith, F. Rougeon
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 June 1986
Evidence for the existence of a remnant protein gene in the 423 nucleotide long G-L intergenic region of rabies intergenic regions is presented and is discussed in terms of the evolution of unsegmented negative-strand RNA viruses.
Crystal structures of a template‐independent DNA polymerase: murine terminal deoxynucleotidyltransferase
The crystal structure of the catalytic core of murine terminal deoxynucleotidyltransferase (TdT) at 2.35 Å resolution reveals a typical DNA polymerase β‐like fold locked in a closed form, suggesting a common two metal ions mechanism of nucleotidol transfer in these two proteins.
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.
A procedure is described for the large-scale purification of light (L) and heavy (H) chain mRNAs from plasmacytomas produced in mice by oligo(dT)-cellulose chromatography and either sucrose gradient centrifugation in conditions preventing aggregation or by means of high-resolution preparative gel electrophoresis under non-denaturing conditions.
Completion of the rabies virus genome sequence determination: highly conserved domains among the L (polymerase) proteins of unsegmented negative-strand RNA viruses.
The terminal complementarity observed in the rabies genome suggests the conservation of important genomic signals, and provides further evidence for a common ancestry of Rhabdoviridae and Paramyxovir families.
Terminal Deoxynucleotidyl Transferase Indiscriminately Incorporates Ribonucleotides and Deoxyribonucleotides*
- J. Boulé, F. Rougeon, C. Papanicolaou
- Biology, MedicineThe Journal of Biological Chemistry
- 17 August 2001
An essential catalytic aspartate in TdT was identified, which is a first step toward understanding the apparent lack of sugar discrimination by Td T, and reflects an impeded accommodation of ribo- or mixed ribo/deoxyribonucleic acid substrates by T dT.
Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation.
- P. Lafaye, I. Achour, P. England, C. Duyckaerts, F. Rougeon
- Chemistry, MedicineMolecular immunology
- 1 February 2009
It is confirmed that VHHs may recognize non-conventional epitopes and illustrates their potential for the immunodiagnostic of diseases due to protein accumulation and the generation of novel camelid single-chain binding domains (VHHs) that recognizes specifically low molecular-weight oligomers.
Host Alternation Is Necessary to Maintain the Genome Stability of Rift Valley Fever Virus
- S. Moutailler, B. Roche, J. Thiberge, V. Caro, F. Rougeon, A. Failloux
- Biology, MedicinePLoS neglected tropical diseases
- 1 May 2011
The results strongly support the view that alternating replication is necessary to maintain the virulence factor carried by the NSs phosphoprotein.
Conferring a template-dependent polymerase activity to terminal deoxynucleotidyltransferase by mutations in the Loop1 region
- F. Romain, I. Barbosa, J. Gouge, F. Rougeon, M. Delarue
- Biology, MedicineNucleic acids research
- 5 June 2009
Attempts to transform Tdt into pol μ with the minimal number of mutations in and around Loop1 are described, and the single-point mutant F401A displays a sequence-specific replicative polymerase phenotype that is stable upon Co++ addition.
Cell‐penetrating anti‐GFAP VHH and corresponding fluorescent fusion protein VHH‐GFP spontaneously cross the blood‐brain barrier and specifically recognize astrocytes: application to brain imaging
- Tengfei Li, J. Bourgeois, +8 authors P. Lafaye
- Biology, MedicineFASEB journal : official publication of the…
- 1 October 2012
It is demonstrated for the first time that a new class of antibodies can cross the blood‐brain barrier without treatment and specifically recognize astrocytes: application to brain imaging.
Tetrameric and Homodimeric Camelid IgGs Originate from the Same IgH Locus
- I. Achour, P. Cavelier, Magali Tichit, C. Bouchier, P. Lafaye, F. Rougeon
- Biology, MedicineThe Journal of Immunology
- 1 August 2008
Analysis of cDNA coding for the membrane forms of IgG and IgM present in alpaca peripheral blood B cells are most consistent with the notion that the development of a B cell bearing homodimeric IgG passes through an IgM+ stage, similar to the case for conventional IgG.