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The Genetic Landscape of a Cell
Making Connections Genetic interaction profiles highlight cross-connections between bioprocesses, providing a global view of cellular pleiotropy, and enable the prediction of genetic network hubs.Expand
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Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation
Whole-genome mRNA quantitation can be used to identify the genes that are most responsive to environmental or genotypic change. By searching for mutually similar DNA elements among the upstreamExpand
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Towards a proteome-scale map of the human protein–protein interaction network
Systematic mapping of protein–protein interactions, or ‘interactome’ mapping, was initiated in model organisms, starting with defined biological processes and then expanding to the scale of theExpand
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Global Mapping of the Yeast Genetic Interaction Network
A genetic interaction network containing ∼1000 genes and ∼4000 interactions was mapped by crossing mutations in 132 different query genes into a set of ∼4700 viable gene yeast deletion mutants andExpand
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Evidence for dynamically organized modularity in the yeast protein–protein interaction network
In apparently scale-free protein–protein interaction networks, or ‘interactome’ networks, most proteins interact with few partners, whereas a small but significant proportion of proteins, the ‘hubs’,Expand
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Characterizing gene sets with FuncAssociate
SUMMARY FuncAssociate is a web-based tool to help researchers use Gene Ontology attributes to characterize large sets of genes derived from experiment. Expand
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High-Quality Binary Protein Interaction Map of the Yeast Interactome Network
Current yeast interactome network maps contain several hundred molecular complexes with limited and somewhat controversial representation of direct binary interactions. We carried out a comparativeExpand
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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases such as cancer. To extend the catalog ofExpand
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Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans
Differential regulation of gene expression is essential for cell fate specification in metazoans. Characterizing the transcriptional activity of gene promoters, in time and in space, is therefore aExpand
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A Map of the Interactome Network of the Metazoan C. elegans
To initiate studies on how protein-protein interaction (or “interactome”) networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactomeExpand
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