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Regulation of intrinsic neuronal properties for axon growth and regeneration
Efficient therapeutic interventions in the injured CNS should combine targeted manipulations of growth control mechanisms with task-specific training and rehabilitation paradigms to maintain specific patterns of connectivity in the highly complex mammalian CNS. Expand
Neurogenesis in the Cerebellum
  • B. Carletti, F. Rossi
  • Biology, Medicine
  • The Neuroscientist : a review journal bringing…
  • 1 February 2008
The authors review cerebellar neurogenesis and discuss the fate mapping studies with other new information stemming from transplantation experiments, in an effort to link the developmental potential of neural progenitor populations of the cerebellum with their spatio-temporal origin. Expand
Different Types of Cerebellar GABAergic Interneurons Originate from a Common Pool of Multipotent Progenitor Cells
Contrary to other cerebellar types, GABAergic interneurons are produced by a common pool of progenitors, which maintain their full developmental potentialities up to late ontogenetic stages and adopt mature identities in response to local instructive cues. Expand
Experience-Dependent Plasticity and Modulation of Growth Regulatory Molecules at Central Synapses
The observations show that the maintenance and growth-inhibitory function of perineuronal nets are regulated by a dynamic interplay between pre- and postsynaptic neurons, and external stimuli act on this interaction to facilitate neuritic growth by locally dampening the activity of inhibitory cues. Expand
Neural stem cell therapy for neurological diseases: dreams and reality
These requirements are examined, the results obtained so far are discussed, and the steps that need to be taken to provide instruction to donor cells and to elucidate the neurogenic potential of the adult central nervous system environment are considered. Expand
Generation of Distinct Types of Periglomerular Olfactory Bulb Interneurons during Development and in Adult Mice: Implication for Intrinsic Properties of the Subventricular Zone Progenitor Population
Hochronic/heterochronic transplantation demonstrates that progenitor cells isolated from the LGE or SVZ at different stages engraft into the SVZ of neonatal or adult mice, migrate to the OB, and differentiate into local interneurons, including granule and periglomerular cells as well as other types of interneuronons. Expand
Origin, lineage and function of cerebellar glia
It is proposed that Bergmann glia exerts a crucial scaffolding activity that, together with the organizing function of Purkinje cells, is necessary to achieve the normal pattern of foliation and layering of the cerebellar cortex. Expand
Origins and control of the differentiation of inhibitory interneurons and glia in the cerebellum.
The results indicate that Ascl1 directs ventricular neuroepithelium progenitors towards inhibitory interneuron fate and restricts their ability to differentiate along the astroglial lineage. Expand
Laminar Fate and Phenotype Specification of Cerebellar GABAergic Interneurons
In most CNS regions, the variety of inhibitory interneurons originates from separate pools of progenitors residing in discrete germinal domains, where they become committed to specific phenotypes andExpand
Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development
It is demonstrated that, in the absence of Neurog2, both cell-cycle progression and neuronal output are significantly affected, leading to an overall reduction of the mature cerebellar volume. Expand