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Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy
Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior studies, we have defined gene expression… Expand
Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation.
- Martin Lauss, R. Haq, +15 authors G. Jönsson
- Biology, Medicine
- The Journal of investigative dermatology
- 1 July 2015
The microphthalmia-associated transcription factor (MITF) is a key regulator of melanocyte development and a lineage-specific oncogene in melanoma; a highly lethal cancer known for its unpredictable… Expand
Clinical framework for next generation sequencing based analysis of treatment predictive mutations and multiplexed gene fusion detection in non-small cell lung cancer
Precision medicine requires accurate multi-gene clinical diagnostics. We describe the implementation of an Illumina TruSight Tumor (TST) clinical NGS diagnostic framework and parallel validation of a… Expand
Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical trials in melanoma; however, 50–60% of the… Expand
Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma.
Cancer genome sequencing has shed light on the underlying genetic aberrations that drive tumorigenesis. However, current sequencing-based strategies, which focus on a single tumor biopsy, fail to… Expand
Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer
Large cell carcinoma with or without neuroendocrine features (LCNEC and LC, respectively) constitutes 3–9% of non-small cell lung cancer but is poorly characterized at the molecular level. Herein we… Expand
The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma.
The X-linked DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase frequently altered in various human cancers, including melanomas. Despite its important roles in translation and splicing, how… Expand
Genetic variation in the moss Homalothecium lutescens in relation to habitat age and structure
Relationships between genetic (allozyme) variation and landscape age and structure were investigated in 17 calcareous grassland demes of the moss Homalothecium lutescens (Hedw.) H. Rob. on the Baltic… Expand
Sexual reproduction in the phyllodioicous bryophyte Homalothecium lutescens (Hedw.) H.Rob. in relation to habitat age, growth conditions and genetic variation
Abstract Sporophyte production and female fertility were investigated in seventeen calcareous grassland demes of the moss Homalothecium lutescens (Hedw.) H.Rob. on the Baltic island of Öland, with… Expand
Author Correction: Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.