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Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis.
The findings suggest that meningeal infiltrates may play a contributory role in the underlying subpial grey matter pathology and accelerated clinical course, which is exacerbated in a significant proportion of cases by the presence of B cell follicle-like structures. Expand
A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis
Evaluated the cellular substrates of the cortical damage to understand the role of meningeal inflammation in MS pathology and identified ectopic B‐cell follicle‐like structures in the meninges. Expand
Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis.
The data suggest that generalized diffuse meningeal inflammation and the associated inflammatory milieu in the subarachnoid compartment plays a role in the pathogenesis of cortical grey matter lesions and an increased rate of clinical progression in primary progressive multiple sclerosis. Expand
`Spindle Cell Oncocytoma' of the Adenohypophysis: A Tumor of Folliculostellate Cells?
The histologic, immunohistochemical, and fine structural features of these tumors were unlike those of pituitary adenoma or any other primary sellar tumor. Expand
Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia
It is shown that microglial-derived ANxA1 is fundamental for brain homeostasis, and it is suggested that ANXA1 and its peptidomimetics can be novel therapeutic targets in neuroinflammation. Expand
Reference and target region modeling of [11C]-(R)-PK11195 brain studies.
UNLABELLED PET with [(11)C]-(R)-PK11195 is currently the modality of choice for the in vivo imaging of microglial activation in the human brain. In this work we devised a supervised clusteringExpand
Incidence and spectrum of sporadic Creutzfeldt–Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification
The present data provide an updated disease classification and are of importance for future epidemiologic and transmission studies aimed to identify etiology and extent of strain variation in sporadic Creutzfeldt–Jakob disease. Expand
The neuropathological basis of clinical progression in multiple sclerosis
The contributions that the various types of pathology are likely to make to the increasing neurological deficit in MS are reviewed. Expand
SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary.
Low levels of expression of SSTR2 may account for the limited response of GPAs to octreotide and lanreotide, and targeting this receptor with a multireceptor ligand SSA such as pasireotide may be indicated for potentially aggressive GPAs. Expand
Chordoid Glioma of the Third Ventricle: An Ultrastructural Study of Three Cases With a Histogenetic Hypothesis
It is suggested that chordoid glioma may represent a subtype of ependymoma whose cells resemble the highly specialized ependyma of the subcommissural organ. Expand