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A methodological bias toward overestimation of molecular evolutionary time scales
There is presently a conflict between fossil- and molecular-based evolutionary time scales. Molecular approaches for dating the branches of the tree of life frequently lead to substantially deeperExpand
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Tree rooting with outgroups when they differ in their nucleotide composition from the ingroup: the Drosophila saltans and willistoni groups, a case study.
Rooting is frequently the most precarious step in any phylogenetic analysis. Outgroups can become useless for rooting if they are too distantly related to the ingroup. Specifically, little attentionExpand
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Origins and evolution of spliceosomal introns.
Research into the origins of introns is at a critical juncture in the resolution of theories on the evolution of early life (which came first, RNA or DNA?), the identity of LUCA (the last universalExpand
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Ribonucleotide Reductases: Divergent Evolution of an Ancient Enzyme
Abstract. Ribonucleotide reductases (RNRs) are uniquely responsible for converting nucleotides to deoxynucleotides in all dividing cells. The three known classes of RNRs operate through a freeExpand
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Shared nucleotide composition biases among species and their impact on phylogenetic reconstructions of the Drosophilidae.
Compositional changes are a major feature of genome evolution. Overlooking nucleotide composition differences among sequences can seriously mislead phylogenetic reconstructions. Large compositionalExpand
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New Drosophila introns originate by duplication.
We have analyzed the phylogenetic distribution of introns in the gene coding for xanthine dehydrogenase in 37 species, including 31 dipterans sequenced by us. We have discovered three narrowlyExpand
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Plant progesterone 5β-reductase is not homologous to the animal enzyme. Molecular evolutionary characterization of P5βR from Digitalis purpurea
Abstract Plants of the genus Digitalis produce cardiac glycosides, i.e. digoxin, which are widely used for congestive heart failure. Progesterone 5β-reductase (P5βR) is a key enzyme in theExpand
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Switch in codon bias and increased rates of amino acid substitution in the Drosophila saltans species group.
We investigated the nucleotide composition of five genes, Xdh, Adh, Sod, Per, and 28SrRNA, in nine species of Drosophila (subgenus Sophophora) and one of Scaptodrosophila. The six species of theExpand
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Fluctuating Mutation Bias and the Evolution of Base Composition in Drosophila
Abstract. The idea that the pattern of point mutation in Drosophila has remained constant during the evolution of the genus has recently been challenged. A study of the nucleotide composition focusedExpand
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Alternative splicing: A missing piece in the puzzle of intron gain
Spliceosomal introns, a hallmark of eukaryotic gene organization, were an unexpected discovery. After three decades, crucial issues such as when and how introns first appeared in evolution remainExpand
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