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Topics in herpesvirus genomics and evolution.
Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1.
Identification and Characterization of a Novel Non-Structural Protein of Bluetongue Virus
This study suggests that NS4 plays an important role in virus-host interaction and is one of the mechanisms played, at least by BTV-8, to counteract the antiviral response of the host.
Identification and Characterization of a Herpes Simplex Virus Gene Product Required for Encapsidation of Virus DNA
A mutant of herpes simplex virus type 1, 17tsVP1201, has a temperature-sensitive processing defect in a late virus polypeptide, suggesting that the defect of the mutant was in the gene encoding p40 rather than in a gene of a processing enzyme.
Herpesvirus Capsid Association with the Nuclear Pore Complex and Viral DNA Release Involve the Nucleoporin CAN/Nup214 and the Capsid Protein pUL25
It is shown that herpes simplex virus type 1 (HSV-1) capsids interact with the nucleoporin CAN/Nup214 in infected cells and that RNA silencing of CAN/nup214 delays the onset of viral DNA replication in the nucleus.
Common Ancestry of Herpesviruses and Tailed DNA Bacteriophages
Comparative analysis of capsid protein structures in the eukaryote-infecting herpesviruses and the prokaryote -infecting tailed DNA bacteriophages revealed a characteristic fold that is restricted to these two virus lineages and is indicative of common ancestry.
Visualization of Tegument-Capsid Interactions and DNA in Intact Herpes Simplex Virus Type 1 Virions
Herpes simplex virus type 1 virions were examined by electron cryomicroscopy, allowing the three-dimensional structure of the infectious particle to be visualized for the first time, suggesting a spool model for DNA packaging, similar to that for some bacteriophages.
Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins.
Electron microscope examination of insect cells coinfected with recombinant baculoviruses expressing VP19C and VP5 reveals the presence of 70 nm diameter 'capsid-like' structures, suggesting that these two proteins can form the basic capsid shell.
Protein subunit structures in the herpes simplex virus A-capsid determined from 400 kV spot-scan electron cryomicroscopy.
- Z. Zhou, B. Prasad, J. Jakana, F. Rixon, W. Chiu
- Biology, ChemistryJournal of molecular biology
- 29 September 1994
The three-dimensional structure of the A-capsid of herpes simplex virus type-1 has been determined by using 400 kV spot-scan electron cryomicroscopy and computer image reconstruction techniques to provide further evidence for the assignment of the four major capsid proteins to these various subunits.
Structure of the herpesvirus major capsid protein
- B. R. Bowman, M. Baker, F. Rixon, W. Chiu, F. Quiocho
- Biology, ChemistryThe EMBO journal
- 17 February 2003
The structure of HSV‐1 capsid revealed a novel fold, placing herpesviruses outside any of the structurally linked viral groupings, the first for any capsid protein from Herpesviridae.