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Insulin and insulin‐like growth factor‐1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways
Insulin and insulin‐like growth factor (IGF‐1) are mitogenic for fibroblasts and smooth muscle cells. IGF‐1 increases in inflamed and fibrotic tissues and induces proliferation of rat hepaticExpand
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Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
BACKGROUND & AIMS The ligand-dependent transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) is expressed in hepatic stellate cells (HSC), and its transcriptional activityExpand
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Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2‐mediated mechanism
Experimental evidence indicates that reactive oxygen species (ROS) are involved in the development of hepatic fibrosis; they induce hepatic stellate cells (HSC) proliferation and collagen synthesis.Expand
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Fibrogenic effect of oxidative stress on rat hepatic stellate cells
Oxidative stress is associated with liver fibrosis and with hepatic stellate cell (HSC) activation in vivo. However, it remains controversial whether oxidative stress contributes to HSC activationExpand
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Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production.
BACKGROUND/AIMS Pirfenidone has been recently shown to reduce dimethynitrosamine-induced liver fibrosis in the rat, but no information are available on the effect of this drug on cultured hepaticExpand
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Post-load insulin resistance is an independent predictor of hepatic fibrosis in virus C chronic hepatitis and in non-alcoholic fatty liver disease
Background: Insulin resistance is a significant risk factor for hepatic fibrosis in patients with both non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC), either directly or byExpand
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Nutrient fluxes from the Ebro River and subsequent across-shelf dispersion
Abstract Coastal areas receive significant amounts of nutrients (nitrogen, phosphorus, silicon) mostly from land-based sources, which contribute to increased biological productivity often exceedingExpand
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Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor.
BACKGROUND & AIMS Hepatic stellate cell (HSC) proliferation is a key event in the development of liver fibrosis. In many liver diseases, HSCs are exposed to inflammatory cytokines, reactive oxygenExpand
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Intracellular pH regulation and Na+/H+ exchange activity in human hepatic stellate cells: effect of platelet-derived growth factor, insulin-like growth factor 1 and insulin.
BACKGROUND/AIMS The Na+/H+ exchanger is involved in rat hepatic stellate cell (HSC) proliferation induced by platelet-derived growth factor (PDGF). We therefore evaluated in human HSC: (1) theExpand
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The molecular basis of β-thalassemia in Turkey
SummaryBy using oligonucleotide hybridization, restriction endonuclease analysis and direct sequencing of amplified genomic DNA, we have been able to characterize 18 different mutations in theExpand
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