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Mechanisms for Solvent Tolerance in Bacteria*
Mutants unable to carry out cis → trans isomerization of unsaturated lipids, that exhibit altered cell envelopes because of the lack of the OprL protein, or that are unable to exclude toluene from cell membranes are hypersensitive to toluenes. Expand
The marine biodiscovery pipeline and ocean medicines of tomorrow
Marine organisms possess the capacity to produce a variety of unique and biologically potent natural products for treating human diseases, many of which are currently commercially available or are inExpand
Hitting the Caspofungin Salvage Pathway of Human-Pathogenic Fungi with the Novel Lasso Peptide Humidimycin (MDN-0010)
By combining humidimycin and caspofungin, a strong increase in casp ofungin efficacy was achieved, demonstrating that targeting different signaling pathways provides an excellent basis to develop novel anti-infective strategies. Expand
Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris
Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range, and corrects that previously assigned to PM181104. Expand
Sponge-Derived Kocuria and Micrococcus spp. as Sources of the New Thiazolyl Peptide Antibiotic Kocurin
Three independent isolates were shown to produce a new anti-MRSA bioactive compound that was identified as kocurin, a new member of the thiazolyl peptide family of antibiotics emphasizing the role of this family as a prolific resource for novel drugs. Expand
Aplicyanins A–F, new cytotoxic bromoindole derivatives from the marine tunicate Aplidium cyaneum
Abstract Six new bromoindole derivatives, aplicyanins A–F ( 1 – 6 ), have been isolated from the CH 2 Cl 2 /MeOH extract of the tunicate Aplidium cyaneum collected in Antarctica. Their structuresExpand
(2α,3β)‐2,3‐Dihydroxyolean‐12‐en‐28‐oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells
It is demonstrated for the first time that, in tumoural cancer cells, maslinic acid exerts a significant anti‐proliferation effect by inducing an apoptotic process characterized by caspase‐3 activation by a p53‐independent mechanism, which occurs via mitochondrial disturbances and cytochrome c release. Expand
Combined LC/UV/MS and NMR Strategies for the Dereplication of Marine Natural Products.
A brief survey of the most robust LC/UV/MS- and NMR-based approaches employed for marine natural product dereplication is presented alongside a description of the procedures followed to achieve this goal in this research group. Expand
PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A
Two new bioactive polyhydroxyl macrolide lactones were isolated from the culture broth of the marine-derived Streptomyces caniferus GUA-06-05-006A, showing potent cytotoxicity against three human tumor cell lines and slight antifungal activity against Candida albicans ATCC10231. Expand
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
Two cytotoxic alkaloids were isolated from Latrunculia brevis and their structures assigned on the basis of detailed spectroscopic analysis and comparison with the known metabolites discorhabdins R, D, and B. Expand