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WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra
Members of the Wnt/wingless family of secreted proteins act as short-range inducers and long-range organizers during axis formation, organogenesis and tumorigenesis in many developing tissues. WntExpand
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Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points.
Left-right (LR) asymmetry is regulated by early asymmetric signals within the embryo. Even though the role of the bone morphogenetic protein (BMP) pathway in this process has been reportedExpand
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FGF signalling controls formation of the apical sensory organ in the cnidarian Nematostella vectensis
Fibroblast growth factor (FGF) signalling regulates essential developmental processes in vertebrates and invertebrates, but its role during early metazoan evolution remains obscure. Here, we analyseExpand
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Wnt/β-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra
In and evaginations of 2D cell sheets are major shape generating processes in animal development. They result from directed movement and intercalation of polarized cells associated with cell shapeExpand
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Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: implications for the evolution of axial patterning.
The evolutionary origin of the anterior-posterior and the dorsoventral body axes of Bilateria is a long-standing question. It is unclear how the main body axis of Cnidaria, the sister group to theExpand
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Nervous systems of the sea anemone Nematostella vectensis are generated by ectoderm and endoderm and shaped by distinct mechanisms
As a sister group to Bilateria, Cnidaria is important for understanding early nervous system evolution. Here we examine neural development in the anthozoan cnidarian Nematostella vectensis in orderExpand
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The Bilaterian Head Patterning Gene six3/6 Controls Aboral Domain Development in a Cnidarian
Characterization of bilaterian head patterning genes in a cnidarian reveals a key role for six3/6 in aboral domain development and provides new insight into the evolutionary origin of headExpand
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Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements
Bilaterian animals have a Hox gene cluster essential for patterning the main body axis, and a ParaHox gene cluster. Comparison of Hox and ParaHox genes has led workers to postulate that both clustersExpand
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An ancient chordin-like gene in organizer formation of Hydra
Signaling centers or organizers play a key role in axial patterning processes in animal embryogenesis. The function of most vertebrate organizers involves the activity of secreted antagonists of boneExpand
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RGM regulates BMP-mediated secondary axis formation in the sea anemone Nematostella vectensis.
Patterning of the metazoan dorsoventral axis is mediated by a complex interplay of BMP signaling regulators. Repulsive guidance molecule (RGM) is a conserved BMP coreceptor that has not beenExpand
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